Application | Comment | Organism |
---|---|---|
medicine | protein phosphatase inhibitor-1-based therapeutic interventions may ameliorate cardiac dysfunction and remodeling in the failing heart, mechanism and mode of action, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
protein phosphatase-1 inhibitor-1 | plays a role in cardiac physiology and pathophysiology, overview | Cavia porcellus | |
protein phosphatase-1 inhibitor-1 | plays a role in cardiac physiology and pathophysiology, overview | Homo sapiens | |
protein phosphatase-1 inhibitor-1 | plays a role in cardiac physiology and pathophysiology, overview | Mus musculus | |
protein phosphatase-1 inhibitor-1 | plays a role in cardiac physiology and pathophysiology, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
sarcoplasmic reticulum | - |
Cavia porcellus | 16529 | - |
sarcoplasmic reticulum | - |
Mus musculus | 16529 | - |
sarcoplasmic reticulum | - |
Homo sapiens | 16529 | - |
sarcoplasmic reticulum | - |
Rattus norvegicus | 16529 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Cavia porcellus | |
Ca2+ | dependent on | Mus musculus | |
Ca2+ | dependent on | Homo sapiens | |
Ca2+ | dependent on | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated lamban + H2O | Cavia porcellus | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? | |
phosphorylated lamban + H2O | Mus musculus | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? | |
phosphorylated lamban + H2O | Homo sapiens | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? | |
phosphorylated lamban + H2O | Rattus norvegicus | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyocyte | - |
Homo sapiens | - |
heart | - |
Cavia porcellus | - |
heart | - |
Mus musculus | - |
heart | - |
Homo sapiens | - |
heart | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated lamban + H2O | - |
Cavia porcellus | lamban + phosphate | - |
? | |
phosphorylated lamban + H2O | - |
Mus musculus | lamban + phosphate | - |
? | |
phosphorylated lamban + H2O | - |
Homo sapiens | lamban + phosphate | - |
? | |
phosphorylated lamban + H2O | - |
Rattus norvegicus | lamban + phosphate | - |
? | |
phosphorylated lamban + H2O | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | Cavia porcellus | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? | |
phosphorylated lamban + H2O | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | Mus musculus | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? | |
phosphorylated lamban + H2O | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | Homo sapiens | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? | |
phosphorylated lamban + H2O | the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview | Rattus norvegicus | lamban + phosphate | dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a | ? |
Synonyms | Comment | Organism |
---|---|---|
PP1 | - |
Cavia porcellus |
PP1 | - |
Mus musculus |
PP1 | - |
Homo sapiens |
PP1 | - |
Rattus norvegicus |
PP2A | - |
Homo sapiens |
protein phosphatase-1 | - |
Cavia porcellus |
protein phosphatase-1 | - |
Mus musculus |
protein phosphatase-1 | - |
Homo sapiens |
protein phosphatase-1 | - |
Rattus norvegicus |
type 1 protein phosphatase | - |
Cavia porcellus |
type 1 protein phosphatase | - |
Mus musculus |
type 1 protein phosphatase | - |
Homo sapiens |
type 1 protein phosphatase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview | Cavia porcellus |
malfunction | perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview | Mus musculus |
malfunction | perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview | Homo sapiens |
malfunction | perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview | Rattus norvegicus |
physiological function | type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview | Cavia porcellus |
physiological function | type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview | Mus musculus |
physiological function | type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview | Homo sapiens |
physiological function | type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview | Rattus norvegicus |