Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.16 extracted from

  • Nicolaou, P.; Hajjar, R.J.; Kranias, E.G.
    Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology (2009), J. Mol. Cell. Cardiol., 47, 365-371.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine protein phosphatase inhibitor-1-based therapeutic interventions may ameliorate cardiac dysfunction and remodeling in the failing heart, mechanism and mode of action, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
protein phosphatase-1 inhibitor-1 plays a role in cardiac physiology and pathophysiology, overview Cavia porcellus
protein phosphatase-1 inhibitor-1 plays a role in cardiac physiology and pathophysiology, overview Homo sapiens
protein phosphatase-1 inhibitor-1 plays a role in cardiac physiology and pathophysiology, overview Mus musculus
protein phosphatase-1 inhibitor-1 plays a role in cardiac physiology and pathophysiology, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
sarcoplasmic reticulum
-
Cavia porcellus 16529
-
sarcoplasmic reticulum
-
Mus musculus 16529
-
sarcoplasmic reticulum
-
Homo sapiens 16529
-
sarcoplasmic reticulum
-
Rattus norvegicus 16529
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Cavia porcellus
Ca2+ dependent on Mus musculus
Ca2+ dependent on Homo sapiens
Ca2+ dependent on Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated lamban + H2O Cavia porcellus the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?
phosphorylated lamban + H2O Mus musculus the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?
phosphorylated lamban + H2O Homo sapiens the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?
phosphorylated lamban + H2O Rattus norvegicus the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
Homo sapiens
-
heart
-
Cavia porcellus
-
heart
-
Mus musculus
-
heart
-
Homo sapiens
-
heart
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated lamban + H2O
-
Cavia porcellus lamban + phosphate
-
?
phosphorylated lamban + H2O
-
Mus musculus lamban + phosphate
-
?
phosphorylated lamban + H2O
-
Homo sapiens lamban + phosphate
-
?
phosphorylated lamban + H2O
-
Rattus norvegicus lamban + phosphate
-
?
phosphorylated lamban + H2O the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview Cavia porcellus lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?
phosphorylated lamban + H2O the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview Mus musculus lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?
phosphorylated lamban + H2O the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview Homo sapiens lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?
phosphorylated lamban + H2O the substrate enzyme regulates the activity of the Ca2+-ATPase pump on the sarcoplasmic reticulum and is a key regulator of both basal contractility and the heart's beta-agonist responses, overview Rattus norvegicus lamban + phosphate dephosphorylated phospholamban exhibits an inhibitory effect on SERCA2a ?

Synonyms

Synonyms Comment Organism
PP1
-
Cavia porcellus
PP1
-
Mus musculus
PP1
-
Homo sapiens
PP1
-
Rattus norvegicus
PP2A
-
Homo sapiens
protein phosphatase-1
-
Cavia porcellus
protein phosphatase-1
-
Mus musculus
protein phosphatase-1
-
Homo sapiens
protein phosphatase-1
-
Rattus norvegicus
type 1 protein phosphatase
-
Cavia porcellus
type 1 protein phosphatase
-
Mus musculus
type 1 protein phosphatase
-
Homo sapiens
type 1 protein phosphatase
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview Cavia porcellus
malfunction perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview Mus musculus
malfunction perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview Homo sapiens
malfunction perturbations in the regulation of PP1 by inhibitor-1 have been implicated in the pathogenesis of heart failure, role of PP1 and protein phosphatase-1 inhibitor-1 in the failing heart, overview Rattus norvegicus
physiological function type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview Cavia porcellus
physiological function type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview Mus musculus
physiological function type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview Homo sapiens
physiological function type 1 protein phosphatase is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it mediates restoration of cardiac function to basal levels, after beta-adrenergic stimulation, by dephosphorylating key phospho-proteins, role of PP1 in the heart and its critical regulation by the endogenous phospho-protein I-1, overview Rattus norvegicus