Literature summary for 3.1.3.16 extracted from

Smit, N.P.; Van Rossum, H.H.; Romijn, F.P.; Sellar, K.J.; Breetveld, M.; Gibbs, S.; Van Pelt, J.
Calcineurin activity and inhibition in skin and (epi)dermal cell cultures (2008), J. Invest. Dermatol., 128, 1686-1690.

Search for more literature for 3.1.3.16

Inhibitors

Inhibitors	Comment	Organism	Structure
cyclosporin A	an immunosuppressive drug. 25% inhibition in keratinocytes at 831 nM, 49% in melanocytes	Homo sapiens
EGTA	-	Homo sapiens
additional information	calcineurin inhibition in fibroblasts and keratinocytes may be of influence on the overall functioning of the skin immune system. No inhibition of calcineurin by okadaic acid	Homo sapiens
pimecrolimus	an immunosuppressive drug	Homo sapiens
tacrolimus	an immunosuppressive drug. 89% inhibition in keratinocytes at 124 nM, 74% in fibroblasts, and 75% in melanocytes	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	calcium-dependent protein phosphatase 2B	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	-	Homo sapiens	-
fibroblast	-	Homo sapiens	-
fibroblast cell line	F0502 cell	Homo sapiens	-
fibroblast cell line	F0503 cell	Homo sapiens	-
keratinocyte	-	Homo sapiens	-
melanocyte	-	Homo sapiens	-
skin	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.0038	0.0077	keratinoyctes	Homo sapiens
0.0085	0.0127	fibroblasts	Homo sapiens

Synonyms

Synonyms	Comment	Organism
calcineurin	-	Homo sapiens
calcium-dependent protein phosphatase 2B	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000004	0.0000013	in fibroblasts	Homo sapiens	tacrolimus
0.000002	0.0000027	in fibroblasts	Homo sapiens	cyclosporin A
0.000006	0.0000201	in fibroblasts	Homo sapiens	pimecrolimus

General Information

General Information	Comment	Organism
malfunction	calcineurin inhibition in fibroblasts and keratinocytes may be of influence on the overall functioning of the skin immune system	Homo sapiens

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Release 2023.1 (January 2023)