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Literature summary for 3.1.3.16 extracted from

  • Eto, M.
    Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors (2009), J. Biol. Chem., 284, 35273-35277.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information PKA is known to phosphorylate and activate PP2A in brain Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CPI-17 encoded by gene PPP1R14A, chromosome 19. Upon phosphorylation at Thr38, the 17 kDa PP1 inhibitor protein, CPI-17, selectively inhibits a specific form of PP1, myosin light chain phosphatase, which transduces multiple kinase signals into the phosphorylation of myosin II and other proteins. Phosphorylation of CPI-17 at Thr38 is necessary and sufficient to convert the protein into a potent MLCP inhibitor, mechanism, modeling, overview Homo sapiens
additional information regulation of cellular PP1 by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors. Mechanisms underlying PP1 inhibition and the kinase/PP1 cross-talk mediated by CPI-17 and its related proteins, PHI, KEPI, and GBPI, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens regulation of cellular PP1 by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors, overview ?
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?
myosin light chain phosphate + H2O Homo sapiens myosin light chain phosphatase is a specific form of PP1 myosin light chain + phosphate
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein PKA is known to phosphorylate and activate PP2A in brain Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
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Homo sapiens
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smooth muscle cell
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Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information regulation of cellular PP1 by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors, overview Homo sapiens ?
-
?
myosin light chain phosphate + H2O myosin light chain phosphatase is a specific form of PP1 Homo sapiens myosin light chain + phosphate
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?

Synonyms

Synonyms Comment Organism
myosin light chain phosphatase a specific form of PP1 Homo sapiens
PP1
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Homo sapiens
protein phosphatase-1
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Homo sapiens

General Information

General Information Comment Organism
malfunction malfunctions of C-kinase-activated PP1 inhibitor proteins are linked to a variety of diseases, including cardiovascular disease and cancer Homo sapiens