Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | PKA is known to phosphorylate and activate PP2A in brain | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CPI-17 | encoded by gene PPP1R14A, chromosome 19. Upon phosphorylation at Thr38, the 17 kDa PP1 inhibitor protein, CPI-17, selectively inhibits a specific form of PP1, myosin light chain phosphatase, which transduces multiple kinase signals into the phosphorylation of myosin II and other proteins. Phosphorylation of CPI-17 at Thr38 is necessary and sufficient to convert the protein into a potent MLCP inhibitor, mechanism, modeling, overview | Homo sapiens | |
additional information | regulation of cellular PP1 by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors. Mechanisms underlying PP1 inhibition and the kinase/PP1 cross-talk mediated by CPI-17 and its related proteins, PHI, KEPI, and GBPI, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | regulation of cellular PP1 by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors, overview | ? | - |
? | |
myosin light chain phosphate + H2O | Homo sapiens | myosin light chain phosphatase is a specific form of PP1 | myosin light chain + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | PKA is known to phosphorylate and activate PP2A in brain | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
smooth muscle cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | regulation of cellular PP1 by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors, overview | Homo sapiens | ? | - |
? | |
myosin light chain phosphate + H2O | myosin light chain phosphatase is a specific form of PP1 | Homo sapiens | myosin light chain + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
myosin light chain phosphatase | a specific form of PP1 | Homo sapiens |
PP1 | - |
Homo sapiens |
protein phosphatase-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | malfunctions of C-kinase-activated PP1 inhibitor proteins are linked to a variety of diseases, including cardiovascular disease and cancer | Homo sapiens |