Inhibitors | Comment | Organism | Structure |
---|---|---|---|
protein phosphatase-1 inhibitor-3 | a potent inhibitor of protein phosphatase-1 that selectively associates with PP1gamma1 and PP1alpha, but not the PP1beta isoform. It is a physiological substrate of caspase-3 harboring a putative caspase-3 cleavage site, 46DTVD49, located between the two PP1 interaction sites, which consist of a RVXF motif and an adjacent inhibitory domain, both of which are required for inhibition of PP1. Inh-3 mutant D49A is caspase-3 resistant | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
additional information | major relocalization of the cellular pool of isozymes PP!alpha and PP1gamma1 from the nucleolus to the nucleus and then to the cytoplasm during actinomycin D-induced apoptosis | Homo sapiens | - |
- |
nucleolus | - |
Homo sapiens | 5730 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is cleaved by caspase-3, PP1 inhibitor Inh3 harbors a putative caspase-3 cleavage site, 46DTVD49, located between the two PP1 interaction sites, which consist of a RVXF motif and an adjacent inhibitory domain, both of which are required for inhibition of PP1 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes PP1alpha, PP1beta, and PP1gamma1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | a promyelocytic leukemia cell line | Homo sapiens | - |
MOLT-4 cell | a T-cell lymphoblastic leukemia cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is cleaved by caspase-3, PP1 inhibitor Inh3 harbors a putative caspase-3 cleavage site, 46DTVD49, located between the two PP1 interaction sites, which consist of a RVXF motif and an adjacent inhibitory domain, both of which are required for inhibition of PP1 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein phosphatase-1 | - |
Homo sapiens |