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Literature summary for 3.1.3.16 extracted from

  • Huang, H.S.; Lee, E.Y.
    Protein phosphatase-1 inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response (2008), J. Biol. Chem., 283, 18135-18146.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
protein phosphatase-1 inhibitor-3 a potent inhibitor of protein phosphatase-1 that selectively associates with PP1gamma1 and PP1alpha, but not the PP1beta isoform. It is a physiological substrate of caspase-3 harboring a putative caspase-3 cleavage site, 46DTVD49, located between the two PP1 interaction sites, which consist of a RVXF motif and an adjacent inhibitory domain, both of which are required for inhibition of PP1. Inh-3 mutant D49A is caspase-3 resistant Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
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Homo sapiens 5737
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additional information major relocalization of the cellular pool of isozymes PP!alpha and PP1gamma1 from the nucleolus to the nucleus and then to the cytoplasm during actinomycin D-induced apoptosis Homo sapiens
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nucleolus
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Homo sapiens 5730
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nucleus
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Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is cleaved by caspase-3, PP1 inhibitor Inh3 harbors a putative caspase-3 cleavage site, 46DTVD49, located between the two PP1 interaction sites, which consist of a RVXF motif and an adjacent inhibitory domain, both of which are required for inhibition of PP1 ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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isozymes PP1alpha, PP1beta, and PP1gamma1
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Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell a promyelocytic leukemia cell line Homo sapiens
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MOLT-4 cell a T-cell lymphoblastic leukemia cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is cleaved by caspase-3, PP1 inhibitor Inh3 harbors a putative caspase-3 cleavage site, 46DTVD49, located between the two PP1 interaction sites, which consist of a RVXF motif and an adjacent inhibitory domain, both of which are required for inhibition of PP1 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
protein phosphatase-1
-
Homo sapiens