Inhibitors | Comment | Organism | Structure |
---|---|---|---|
microcystin | inhibits by binding tightly to the phosphatase catalytic domain of PP5 | Trypanosoma brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | under normal growth conditions, PP5 is primarily localized in the cytosol | Trypanosoma brucei | 5829 | - |
nucleus | with increase in growth temperature (up to 40°C) and geldanamycin treatment, PP5 translocates to the nucleus | Trypanosoma brucei | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Purification (Comment) | Organism |
---|---|
microcystin-Sepharose bead chromatography | Trypanosoma brucei |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated Hsp90 + H2O | PP5 positively regulates the function of Hsp90 to maintain cellular homeostasis during proteotoxic stresses | Trypanosoma brucei | Hsp90 + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PP5 | - |
Trypanosoma brucei |
protein phosphatase 5 | - |
Trypanosoma brucei |