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Literature summary for 3.1.3.16 extracted from

  • Mourtada-Maarabouni, M.; Williams, G.T.
    Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells (2008), Biochim. Biophys. Acta, 1783, 1490-1502.
    View publication on PubMed

Application

Application Comment Organism
medicine PP4 regulates both apoptosis and proliferation in human cells and the level of PP4 has a strong influence on gene mutation rate, which is crucial to oncogenesis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells, PP4c over-expressing cells are consistently more sensitive to UV-, cisplatin-, butyrate- and okadaic acid-induced cell death Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm some PP4c is cytoplasmic Homo sapiens 5737
-
nucleus the subcellular localisation of PP4c is mainly nuclear Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
catalytic subunit PP4c, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoprotein + H2O
-
Homo sapiens protein + phosphate
-
?

Synonyms

Synonyms Comment Organism
Pp4
-
Homo sapiens
PP4c catalytic subunit of protein phosphatase 4 Homo sapiens
protein phosphatase 4
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
Calmodulin
-
Homo sapiens