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Literature summary for 3.1.3.16 extracted from

  • Foley, T.D.; Petro, L.A.; Stredny, C.M.; Coppa, T.M.
    Oxidative inhibition of protein phosphatase 2A activity: role of catalytic subunit disulfides (2007), Neurochem. Res., 32, 1957-1964.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol phosphatase activity is increased to up to 49-62% by 3 mM Rattus norvegicus
dithiothreitol phosphatase activity is increased to up to 49-62% by 0.3 mM Rattus norvegicus
tris(2-carboxyethyl)-phosphine hydrochloride phosphatase activity is increased to up to 49-62% by 0.3 mM Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptoethanol phosphatase activity is decreased by 5 mM Rattus norvegicus
dithiothreitol phosphatase activity is decreased by 5 mM Rattus norvegicus
okadaic acid 91% inhibition of the total phosphatase activity Rattus norvegicus
Phenylarsine oxide potent dithiothreitol-reversible inhibition of PP2A Rattus norvegicus
tris(2-carboxyethyl)-phosphine hydrochloride phosphatase activity is decreased by 5 mM Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
1 * 35000 + 1 * 32000, SDS-PAGE Rattus norvegicus
35000
-
1 * 35000 + 1 * 32000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Bio-Gel P-6 gel filtration Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
cerebral cortex
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
KRpTIRR + H2O
-
Rattus norvegicus KRTIRR + phosphate
-
?

Subunits

Subunits Comment Organism
dimer 1 * 35000 + 1 * 32000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
PP2Ac
-
Rattus norvegicus
protein phosphatase 2A
-
Rattus norvegicus
serine/threonine phosphatase
-
Rattus norvegicus