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Literature summary for 3.1.3.16 extracted from

  • Arnold, H.K.; Sears, R.C.
    Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation (2006), Mol. Cell. Biol., 26, 2832-2844.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.16

Cloned(Commentary)

Cloned (Comment) Organism
co-overexpression of HA-tagged PP2A catalytic subunit and regulatory subunit B56alpha, with c-Myc in HEK-293 cells, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information inhibition of PP2A-B56alpha by specific small hairpin RNA leads to c-Myc overexpression, elevated levels of c-Myc Ser62 phosphorylation, increased c-Myc activity, and can lead to cell transformation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
small T antigen of SV40 virus specifically inhibits PP2A holoenzymes with B55 or B56 regulatory subunits Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated c-Myc + H2O Homo sapiens PP2A plays an important role in control of proto-oncogene c-Myc by destabilization of c-Myc and promotion of its ubiquitin-mediated degradation, PP2a has tumor-suppressor activity, c-Myc regulation is essential for normal cell function, overview c-Myc + phosphate
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated c-Myc + H2O PP2A plays an important role in control of proto-oncogene c-Myc by destabilization of c-Myc and promotion of its ubiquitin-mediated degradation, PP2a has tumor-suppressor activity, c-Myc regulation is essential for normal cell function, overview Homo sapiens c-Myc + phosphate
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 ?
phosphorylated c-Myc + H2O dephosphorylation of Ser62, PP2A binds to c-Myc via targeting by regulatory subunit B56alpha, overview Homo sapiens c-Myc + phosphate
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Subunits

Subunits Comment Organism
More regulatory subunit B56alpha forms a holoenzyme with the PP2A catalytic subunit Homo sapiens

Synonyms

Synonyms Comment Organism
protein phosphatase 2A regulatory subunit B56alpha
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 Homo sapiens