Protein Variants | Comment | Organism |
---|---|---|
additional information | HME cell treatment with siRNA for PP2A regulatory subunit A causes disruption of cell-cell adhesion and F-actin assembly without affecting the complex formation of E-cadherin with beta-and alpha-catenins, PP2A inactivation induces the dissociation of IQGAP1 from the E-cadheri-catenins complex | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
okadaic acid | PP2A inhibition induces the dissociation of IQGAP1 from the E-cadheri-catenins complex | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PP2A is involved in the maintenance of E-cadherin-mediated cell-cell adhesion through recruitment of IQGAP1, an effector of small GTPase Rac | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HME cell | PP2A is localized in the cell-cell adhesion sites between adjacent cells and associated with E-cadherin-cateinins complex in healthy human mammary epithelial HME cells | Homo sapiens | - |
mammary gland | epithelium | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PP2A is involved in the maintenance of E-cadherin-mediated cell-cell adhesion through recruitment of IQGAP1, an effector of small GTPase Rac | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PP2A | - |
Homo sapiens |
protein phosphatase 2A | - |
Homo sapiens |