Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.16 extracted from

  • Van Kanegan, M.J.; Adams, D.G.; Wadzinski, B.E.; Strack, S.
    Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt (2005), J. Biol. Chem., 280, 36029-36036.
    View publication on PubMed
Search for more literature for 3.1.3.16

Cloned(Commentary)

Cloned (Comment) Organism
expression of FLAG-tagged PP2A in COS-M6 cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
okadaic acid specific Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus PP2A modulates Akt activity, role of PP2A holoenzyme and subunits in MAPK signaling pathways, overview ?
-
 ?
phosphorylated ERK2 + H2O Rattus norvegicus PP2A acts as a gate-keeper of extracellular signal-regulated kinase, ERK, activity in neuronal PC12 cells, the PP2A regulatory subunits Balpha and Bdelta target the PP2A heterotrimer to dephosphorylate and inactivate ERK, silencing of B subunits leads to hyperactivation of ERK stimulated by constitutively active MEK1, overview ERK2 + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant FLAG-tagged PP2A from COS-M6 cells by immunoaffinity chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
PC6-3 cell neuronal cell line, derived from PC12 cell line Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PP2A modulates Akt activity, role of PP2A holoenzyme and subunits in MAPK signaling pathways, overview Rattus norvegicus ?
-
 ?
phosphorylated ERK2 + H2O PP2A acts as a gate-keeper of extracellular signal-regulated kinase, ERK, activity in neuronal PC12 cells, the PP2A regulatory subunits Balpha and Bdelta target the PP2A heterotrimer to dephosphorylate and inactivate ERK, silencing of B subunits leads to hyperactivation of ERK stimulated by constitutively active MEK1, overview Rattus norvegicus ERK2 + phosphate
-
 ?
phosphorylated ERK2 + H2O dephosphorylation of the activation loop threonine of ERK Rattus norvegicus ERK2 + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PP2A
-
 Rattus norvegicus
protein phosphatase 2A
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus