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Literature summary for 3.1.3.16 extracted from
- Overview of protein serine/threonine phosphatases (2004), Topics in Current Genetics (Arino, J. , Alexander, D. R. Eds. ) Springer, 5, 1-20.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | - |
Homo sapiens |  |
| TFIIF | a transcription factor that binds to the C-terminal domain | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cyclophilin | - |
Homo sapiens | |
| cyclosporin | - |
Homo sapiens | |
| microcystin | - |
Homo sapiens | |
| okadaic acid | - |
Homo sapiens | |
| Protein phosphatase inhibitor-1 | - |
Homo sapiens | |
| protein phosphatase inhibitor-2 | - |
Homo sapiens | |
| tautomycin | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens | |
| Mg2+ | essential for activity | Homo sapiens | |
| Mn2+ | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 57000 | - |
1 * 57000, with fused TPR domain | Homo sapiens |
| 76000 | - |
x * 76000 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phospho-Cdk2 + H2O | Homo sapiens | - |
Cdk6 + phosphate | - |
? | |
| phospho-Cdk6 + H2O | Homo sapiens | - |
Cdk6 + phosphate | - |
? | |
| phospho-MKK + H2O | Homo sapiens | - |
MKK + phosphate | - |
? | |
| phospho-TAK1 + H2O | Homo sapiens | - |
TAK1 + phosphate | - |
? | |
| phosphorylated ILK1 + H2O | Homo sapiens | negative regulation of Wnt signaling | ILK1 + phosphate | - |
? | |
| phosphorylated p38 + H2O | Homo sapiens | - |
p38 + phosphate | - |
? | |
| phosphorylated rhodopsin + H2O | Homo sapiens | - |
rhodopsin + phosphate | - |
? | |
| phosphorylated RNA polymerase II + H2O | Homo sapiens | - |
RNA polymerase II + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| retina | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phospho-Cdk2 + H2O | - |
Homo sapiens | Cdk6 + phosphate | - |
? | |
| phospho-Cdk6 + H2O | - |
Homo sapiens | Cdk6 + phosphate | - |
? | |
| phospho-MKK + H2O | - |
Homo sapiens | MKK + phosphate | - |
? | |
| phospho-TAK1 + H2O | - |
Homo sapiens | TAK1 + phosphate | - |
? | |
| phosphorylated ILK1 + H2O | negative regulation of Wnt signaling | Homo sapiens | ILK1 + phosphate | - |
? | |
| phosphorylated ILK1 + H2O | Wip1 | Homo sapiens | ILK1 + phosphate | - |
? | |
| phosphorylated p38 + H2O | - |
Homo sapiens | p38 + phosphate | - |
? | |
| phosphorylated rhodopsin + H2O | - |
Homo sapiens | rhodopsin + phosphate | - |
? | |
| phosphorylated RNA polymerase II + H2O | - |
Homo sapiens | RNA polymerase II + phosphate | - |
? | |
| phosphorylated RNA polymerase II + H2O | dephosphorylation of the carboxyterminal domain | Homo sapiens | RNA polymerase II + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 76000 | Homo sapiens |
| heterodimer | - |
Homo sapiens |
| heterodimer | and higher molecular mass structures | Homo sapiens |
| heterodimer | with fused calmodulin binding and autoinhibitory domains | Homo sapiens |
| heterotrimer | - |
Homo sapiens |
| monomer | - |
Homo sapiens |
| monomer | 1 * 57000, with fused TPR domain | Homo sapiens |
| monomer | fused collagen homology domain | Homo sapiens |
| monomer | fused PIX binding domain | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CALNA | - |
Homo sapiens |
| CALNB | - |
Homo sapiens |
| CaMIIKPase | - |
Homo sapiens |
| CNAalpha | - |
Homo sapiens |
| CNAbeta | - |
Homo sapiens |
| CNAgamma | - |
Homo sapiens |
| Fcp1 | - |
Homo sapiens |
| FIN13 | - |
Homo sapiens |
| hFEM2 | - |
Homo sapiens |
| ILKAP | - |
Homo sapiens |
| NERPP-2C | - |
Homo sapiens |
| PDP1 | - |
Homo sapiens |
| PDP2 | - |
Homo sapiens |
| POPX1 | - |
Homo sapiens |
| POPX2 | - |
Homo sapiens |
| PP1alpha | - |
Homo sapiens |
| PP1beta | - |
Homo sapiens |
| PP1cgamma | - |
Homo sapiens |
| PP1delta | - |
Homo sapiens |
| PP1gamma | - |
Homo sapiens |
| PP2Aalpha | - |
Homo sapiens |
| PP2Abeta | - |
Homo sapiens |
| PP2Acalpha | - |
Homo sapiens |
| PP2Acbeta | - |
Homo sapiens |
| PP2Balpha | - |
Homo sapiens |
| PP2Bbeta | - |
Homo sapiens |
| PP2Bgamma | - |
Homo sapiens |
| PP2Calpha | - |
Homo sapiens |
| PP2Cbeta | - |
Homo sapiens |
| PP2Cdelta | - |
Homo sapiens |
| PP2Cgamma | - |
Homo sapiens |
| Pp4 | - |
Homo sapiens |
| PP5 | - |
Homo sapiens |
| PP6 | - |
Homo sapiens |
| PPEF1 | - |
Homo sapiens |
| PPEF2 | - |
Homo sapiens |
| Ppp1calpha | - |
Homo sapiens |
| Ppp1cbeta | - |
Homo sapiens |
| Ppp1cgamma | - |
Homo sapiens |
| Ppp2calpha | - |
Homo sapiens |
| Ppp2cbeta | - |
Homo sapiens |
| Ppp3calpha | - |
Homo sapiens |
| Ppp3cbeta | - |
Homo sapiens |
| Ppp3cgamma | - |
Homo sapiens |
| Ppp4c | - |
Homo sapiens |
| Ppp5c | - |
Homo sapiens |
| Ppp6c | - |
Homo sapiens |
| Ppp7calpha | - |
Homo sapiens |
| Ppp7cbeta | - |
Homo sapiens |
| PPT | - |
Homo sapiens |
| PPX | - |
Homo sapiens |
| Wip1 | - |
Homo sapiens |
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