BRENDA - Enzyme Database
show all sequences of 3.1.3.15

Purification of the bifunctional enzyme imidazoleglycerolphosphate dehydratase-histidinol phosphatase of Salmonella typhimurium

Staples, M.A.; Houston, L.L.; Biochim. Biophys. Acta 613, 210-219 (1980)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.15
-
L-Histidinol phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
46000
-
Mn2+ precipitiation, antibody affinity chromatography, selective proteolysis
Salmonella enterica subsp. enterica serovar Typhimurium
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-histidinol phosphate + H2O
Salmonella enterica subsp. enterica serovar Typhimurium
-
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
Purification (Commentary)
Commentary
Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
202000
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-histidinol phosphate + H2O
-
5531
Salmonella enterica subsp. enterica serovar Typhimurium
L-histidinol + phosphate
-
5531
Salmonella enterica subsp. enterica serovar Typhimurium
?
L-histidinol phosphate + H2O
-
5531
Salmonella enterica subsp. enterica serovar Typhimurium
?
-
-
-
-
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.15
-
L-Histidinol phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
46000
-
Mn2+ precipitiation, antibody affinity chromatography, selective proteolysis
Salmonella enterica subsp. enterica serovar Typhimurium
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-histidinol phosphate + H2O
Salmonella enterica subsp. enterica serovar Typhimurium
-
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
202000
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-histidinol phosphate + H2O
-
5531
Salmonella enterica subsp. enterica serovar Typhimurium
L-histidinol + phosphate
-
5531
Salmonella enterica subsp. enterica serovar Typhimurium
?
L-histidinol phosphate + H2O
-
5531
Salmonella enterica subsp. enterica serovar Typhimurium
?
-
-
-
-
Other publictions for EC 3.1.3.15
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
751106
Jha
Identification and structural ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618, Mycobacterium tuberculosis H37Rv
J. Biol. Chem.
293
10102-10118
2018
-
1
1
1
5
-
6
2
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2
1
3
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5
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1
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9
2
1
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1
1
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5
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2
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1
3
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1
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9
2
1
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1
1
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-
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3
3
-
1
1
750206
Kulis-Horn
Sequence-based identification ...
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum DSM 20300, Corynebacterium glutamicum JCM 1318, Corynebacterium glutamicum LMG 3730, Corynebacterium glutamicum NCIMB 10025
BMC Microbiol.
17
161
2017
1
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1
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1
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3
2
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4
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12
-
25
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1
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22
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2
3
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2
3
2
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1
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3
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2
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5
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2
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12
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12
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2
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22
-
3
3
-
2
4
2
-
-
-
4
6
-
2
2
751088
Ruszkowski
Structural studies of Medicag ...
Medicago truncatula
J. Biol. Chem.
291
9960-9973
2016
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-
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1
1
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1
2
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1
1
1
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4
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1
2
1
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1
1
-
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2
2
-
1
1
750664
Nourbakhsh
Characterization of the inosi ...
Arabidopsis thaliana
Front. Plant Sci.
5
725
2015
-
-
-
-
-
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1
1
1
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4
-
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1
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1
1
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1
1
729588
Van Eldijk
-
Catenane versus ring: do both ...
Acidianus sp.
Chem. Sci.
5
2879-2884
2014
-
-
-
-
-
-
1
3
-
1
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1
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1
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1
1
1
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-
2
1
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730327
Kulis-Horn
Histidine biosynthesis, its re ...
Corynebacterium glutamicum
Microb. Biotechnol.
7
5-25
2014
-
-
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1
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8
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1
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1
1
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724732
van Eldijk
Evidence that the catenane for ...
Acidianus sp., Acidianus sp. A1-3
Chem. Commun. (Camb. )
49
7770-7772
2013
-
-
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1
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3
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2
2
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729039
Smeulders
Diversity and ecophysiology of ...
Acidithiobacillus caldus, Acidithiobacillus caldus 8584, Acidithiobacillus thiooxidans, Acidithiobacillus thiooxidans 2Bp, Acidithiobacillus thiooxidans BBW1, Acidithiobacillus thiooxidans G8, Acidithiobacillus thiooxidans S1p, Acidithiobacillus thiooxidans Sts 4-3, no activity in Acidithiobacillus albertensis strain DSM 14366, no activity in Acidithiobacillus ferrooxidans strain DSM 14882, no activity in Acidithiobacillus thiooxidans strains DSM504 and DSM14887
Appl. Environ. Microbiol.
79
6784-6794
2013
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1
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8
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21
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8
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1
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8
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1
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729227
Ghodge
Structural and mechanistic cha ...
Lactococcus lactis subsp. lactis, Lactococcus lactis subsp. lactis IL1403
Biochemistry
52
1101-1112
2013
-
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1
1
12
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10
-
3
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2
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4
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1
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4
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11
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12
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10
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1
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4
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11
-
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11
11
729930
Smeulders
Bacterial CS2 hydrolases from ...
Acidithiobacillus thiooxidans, Acidithiobacillus thiooxidans 2Bp, Acidithiobacillus thiooxidans BBW1, Acidithiobacillus thiooxidans G8, Acidithiobacillus thiooxidans S1p, Acidithiobacillus thiooxidans Sts 4-3
J. Bacteriol.
195
4046-4056
2013
-
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1
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4
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12
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18
-
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1
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1
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16
2
1
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1
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2
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2
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3
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16
3
3
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3
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723268
Smeulders
Evolution of a new enzyme for ...
Acidianus sp., Acidianus sp. A1-3
Nature
478
412-416
2011
-
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1
1
3
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4
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1
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2
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706327
Petersen
The missing link in plant hist ...
Arabidopsis thaliana
Plant Physiol.
152
1186-1196
2010
-
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1
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1
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1
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701522
Jung
Crystallization and preliminar ...
Thermococcus onnurineus NA1
Acta Crystallogr. Sect. F
65
472-474
2009
-
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1
1
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2
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679393
Marineo
The histidinol phosphate phosp ...
Streptomyces coelicolor, Streptomyces coelicolor A3(2)
Curr. Microbiol.
56
6-13
2008
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1
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46
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680523
Lee
Novel monofunctional histidino ...
Thermococcus onnurineus
J. Bacteriol.
190
2629-2632
2008
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6
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1
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1
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1
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678231
Omi
Crystal structure of monofunct ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Biochemistry
46
12618-12627
2007
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1
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4
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92
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680722
Rangarajan
Structural snapshots of Escher ...
Escherichia coli
J. Biol. Chem.
281
37930-37941
2006
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649241
Omi
Expression, purification and p ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Acta Crystallogr. Sect. D
60
574-576
2004
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1
1
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2
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92
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1
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666098
Brilli
Molecular evolution of hisB ge ...
Salmonella enterica
J. Mol. Evol.
58
225-237
2004
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170826
le Coq
Histidinol phosphate phosphata ...
Bacillus subtilis
J. Bacteriol.
181
3277-3280
1999
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170825
Clark
Buchnera aphidicola (aphid ndo ...
Buchnera aphidicola
Curr. Microbiol.
37
356-358
1998
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1
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170811
Sugiura
-
Improvement of histidine-produ ...
Serratia marcescens
Agric. Biol. Chem.
2
371-377
1987
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170813
Grisolia
Cloning and expression of the ...
Escherichia coli
J. Bacteriol.
151
692-700
1982
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5531
Staples
Purification of the bifunction ...
Salmonella enterica subsp. enterica serovar Typhimurium
Biochim. Biophys. Acta
613
210-219
1980
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5537
Staples
Proteolytic degradation of imi ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Biol. Chem.
254
1395-1401
1979
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170812
Carsiotis
Cross-pathway regulation: tryp ...
Neurospora crassa
J. Bacteriol.
119
889-892
1974
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7
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7
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170814
Houston
Divalent metal Ion effects on ...
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium TA387
Arch. Biochem. Biophys.
162
513-522
1974
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4
1
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7
1
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3
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1
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4
1
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1
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170815
Araki
-
A Biochemical characterization ...
Corynebacterium glutamicum
Agric. Biol. Chem.
38
2219-2225
1974
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170816
Houston
Effect of sulfhydryl reagents ...
Saccharomyces cerevisiae, Salmonella enterica subsp. enterica serovar Typhimurium
Biochim. Biophys. Acta
370
216-226
1974
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10
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4
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4
1
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10
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4
1
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170823
Carsiotis
Cross-pathway regulation: hist ...
Neurospora crassa
J. Bacteriol.
119
893-898
1974
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5535
Brady
Some properties of the catalyt ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Biol. Chem.
248
2588-2592
1973
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2
1
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1
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2
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170817
Millay
Purification and properties of ...
Saccharomyces cerevisiae, Salmonella enterica subsp. enterica serovar Typhimurium
Biochemistry
12
2591-2596
1973
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170824
Brady
New assay for histidinol phosp ...
Saccharomyces cerevisiae, Salmonella enterica subsp. enterica serovar Typhimurium
Anal. Chem.
48
480-482
1972
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2
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4
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170821
Gorman j.A.; Hu
The separation and partial cha ...
Saccharomyces cerevisiae
J. Biol. Chem.
244
1645-1650
1969
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1
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170822
Ames
The biosynthesis of histidine: ...
Escherichia coli, Neurospora crassa
J. Biol. Chem.
226
583-593
1957
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