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Literature summary for 3.1.3.11 extracted from

  • Schabort, D.T.W.P.; Kilian, S.G.; du Preez, J.C.
    Elucidation of new condition-dependent roles for fructose-1,6-bisphosphatase linked to cofactor balances (2017), PLoS ONE, 12, e0177319 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.11

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-fructose 1,6-bisphosphate + H2O Kluyveromyces marxianus
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 D-fructose 6-phosphate + phosphate
-
 ?
D-fructose 1,6-bisphosphate + H2O Kluyveromyces marxianus UFS-2791
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 D-fructose 6-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Kluyveromyces marxianus
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-
-
Kluyveromyces marxianus UFS-2791
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information cells grown on glucose and xylose as respective carbon sources, aerobic conditions, optimization of culture conditions for up-regulation of FBP1 production, overview Kluyveromyces marxianus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-bisphosphate + H2O
-
 Kluyveromyces marxianus D-fructose 6-phosphate + phosphate
-
 ?
D-fructose 1,6-bisphosphate + H2O
-
 Kluyveromyces marxianus UFS-2791 D-fructose 6-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
F16BDEPHOS
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 Kluyveromyces marxianus
FBP1
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 Kluyveromyces marxianus
fructose-1,6-bisphosphatase
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 Kluyveromyces marxianus

Expression

Organism Comment Expression
Kluyveromyces marxianus transcriptional regulation of the enzyme FBPase 1 in response to metabolic fluxes, overview additional information

General Information

General Information Comment Organism
metabolism effects of the enzyme activity on the flux balance analyses of Kluyveromyces marxianus grown on glucose and xylose as respective carbon sources (e.g. cofactor balances and sugar uptake fluxes), simulations, detailed overview. Simulation of anaerobic conditions Kluyveromyces marxianus
metabolism simulation study of yeast metabolism, that investigates the complex interplay between the cofactors ATP, NAD+ and NADP+, in particular, how they may affect the possible roles of fructose-1,6-bisphosphatase, the pentose phosphate pathway, glycerol production and the pyruvate dehydrogenase bypass. Using flux balance analysis, it is found that the potential role of fructose-1,6-bisphosphatase is highly dependent on the cofactor specificity of the oxidative pentose phosphate pathway and on the carbon source. The fructose-1,6-bisphosphatase/phosphofructokinase substrate cycle and its regulation probably plays a key role in energy homeostasis, even in yeasts under selected conditions, which could determine phenotype switching Kluyveromyces marxianus