Literature summary for 3.1.3.11 extracted from

Visinoni, S.; Khalid, N.F.; Joannides, C.N.; Shulkes, A.; Yim, M.; Whitehead, J.; Tiganis, T.; Lamont, B.J.; Favaloro, J.M.; Proietto, J.; Andrikopoulos, S.; Fam, B.C.
The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity (2012), Diabetes, 61, 1122-1132.

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Application

Application	Comment	Organism
medicine	compared with negative littermates, liver-specific FBPase transgenic mice have 50% less adiposity and eat 15% less food but do not have altered energy expenditure. The reduced food consumption is associated with increased circulating leptin and cholecystokinin, elevated fatty acid oxidation, and 3-beta-hydroxybutyrate ketone levels, and reduced appetite-stimulating neuropeptides, neuropeptide Y and Agouti-related peptide	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09467	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
FBP-1	-	Homo sapiens
FBPase	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	compared with negative littermates, liver-specific FBPase transgenic mice have 50% less adiposity and eat 15% less food but do not have altered energy expenditure. The reduced food consumption is associated with increased circulating leptin and cholecystokinin, elevated fatty acid oxidation, and 3-beta-hydroxybutyrate ketone levels, and reduced appetite-stimulating neuropeptides, neuropeptide Y and Agouti-related peptide	Homo sapiens

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Release 2023.1 (January 2023)