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Literature summary for 3.1.3.11 extracted from

  • Rudnitskaya, A.; Huynh, K.; Toeroek, B.; Stieglitz, K.
    Novel heteroaromatic organofluorine inhibitors of fructose-1,6-bisphosphatase (2009), J. Med. Chem., 52, 878-882.
    View publication on PubMed
Search for more literature for 3.1.3.11

Inhibitors

Inhibitors Comment Organism Structure
(1H-indol-1-yl)(4-(trifluoromethyl)phenyl)methanone
-
 Mus musculus
3,5-diphenyl-1-(3-(trifluoromethyl) phenyl)-1H-pyrazole
-
 Mus musculus
ethyl 3,3,3-trifluoro-2-hydroxy-2-(1-methyl-1H-indol-3-yl)propanoate
-
 Mus musculus
ethyl 3-(3,5-dimethyl-1H-pyrrol-2-yl)-4,4,4-trifluoro-3-hydroxybutanoate
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
gel filtration Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-bisphosphate + H2O
-
 Mus musculus D-fructose 6-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
FBPase
-
 Mus musculus
fructose 1,6-bisphosphatase
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0031
-
 pH 7.5, 37°C Mus musculus (1H-indol-1-yl)(4-(trifluoromethyl)phenyl)methanone
0.0048
-
 pH 7.5, 37°C Mus musculus ethyl 3-(3,5-dimethyl-1H-pyrrol-2-yl)-4,4,4-trifluoro-3-hydroxybutanoate
0.0061
-
 pH 7.5, 37°C Mus musculus 3,5-diphenyl-1-(3-(trifluoromethyl) phenyl)-1H-pyrazole
0.0119
-
 pH 7.5, 37°C Mus musculus ethyl 3,3,3-trifluoro-2-hydroxy-2-(1-methyl-1H-indol-3-yl)propanoate