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Literature summary for 3.1.3.11 extracted from

  • Bigl, M.; Jandrig, B.; Horn, L.C.; Eschrich, K.
    Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer (2008), Biochem. Biophys. Res. Commun., 377, 720-724.
    View publication on PubMed
Search for more literature for 3.1.3.11

Application

Application Comment Organism
molecular biology promoter methylation is involved in the regulation of expression of both FBPase isoenzymes in normal human tissues as well as in cancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
astrocytoma cell line cell line 1321N1 Homo sapiens
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breast
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 Homo sapiens
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breast cancer cell
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 Homo sapiens
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CAL-51 cell
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 Homo sapiens
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HeLa cell
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 Homo sapiens
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Hep-G2 cell
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 Homo sapiens
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liver
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 Homo sapiens
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MDA-MB-468 cell
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 Homo sapiens
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additional information in tumor cell lines, demethylation with 5-aza-deoxycytidine activates the expression of both L- and M-fructose 1,6-bisphosphatase. Additional inhibition of histone deacetylase with trichostatin A further increases FBPase mRNA concentrations Homo sapiens
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additional information when non-malignant and malignant tissue samples from the same patient are compared a correlation between an increase of FBPase promoter methylation and a decrease of FBPase mRNA levels is observed Homo sapiens
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muscle
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 Homo sapiens
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SH-SY5Y cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
M-fructose 1,6-bisphosphatase
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 Homo sapiens