Application | Comment | Organism |
---|---|---|
medicine | FBPase regulates endogenous glucose production and whole body glucose homeostasis in a liver-specific transgenic model. Transgenic mouse can serve as a model for testing human FBPase inhibitor compounds with the potential to treat patients with type 2 diabetes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | to determine the role of upregulated liver FBPase in glucose homeostasis human liver FBPase transgenic mice under the control of the transthyretin promoter are generated, expressing the transgene specifically in liver. Hemizygous transgenic mice have an approximately 3fold increase in total liver FBPase mRNA with concomitant increases in FBPase protein and enzyme activity levels. After high-fat feeding, hemizygous transgenics are glucose intolerant compared to wild-type. Homozygous chow-fed transgenic mice show a 5.5fold increase in liver FBPase levels and are glucose intolerant with a significantly higher rate of endogenous glucose production | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
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Synonyms | Comment | Organism |
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FBPase | - |
Homo sapiens |
fructose 1,6-bisphosphatase | - |
Homo sapiens |