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Literature summary for 3.1.3.11 extracted from

  • Zhang, R.; Villeret, V.; Lipscomb, W.N.; Fromm, H.J.
    Kinetics and mechanism of activation and inhibition of porcine liver fructose-1,6-bisphosphatase by monovalent cations (1996), Biochemistry, 35, 3038-3043.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E280Q K+ loses the ability to activate and became a noncompetitive inhibitor Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
Li+ linear competitive inhibitor Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
K+ activates Sus scrofa
K+ Km: 17 mM Sus scrofa
additional information monovalent cations activate by helping the Arg 276 residue "deshield" the partial negative charge on the 1-phosphoryl group of the substrate so that nucleophilic attack on the 1-phosphorus atom is facilitated Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-diphosphate + H2O
-
Sus scrofa D-fructose 6-phosphate + phosphate
-
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