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Literature summary for 3.1.3.11 extracted from
- Fructose-1,6-biphosphatase of the small intestine. Purification and comparison with liver and muscle fructose-1,6-bisphosphatases (1978), J. Biochem., 84, 327-336.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | activation | Mus musculus |  |
| EDTA | activates in the neutral pH-range | Mus musculus | |
| NH4+ | activates | Mus musculus | |
| NH4+ | maximal activation by 0.1 M NH4+ | Mus musculus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Mus musculus | |
| fructose 1,6-diphosphate | concentration required for 50% inhibition is 0.045 mM for the muscle enzyme, 0.060 mM for the intestinal enzyme and 0.065 mM for the liver enzyme | Mus musculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | activates | Mus musculus | |
| K+ | maximal activation by 0.15 M K+ | Mus musculus | |
| Mg2+ | required | Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 38000 | - |
x * 38000, SDS-PAGE | Mus musculus |
| 140000 | - |
gel filtration | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| enzyme from small intestine | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| muscle | - |
Mus musculus | - |
| small intestine | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 5.3 | - |
pH 9.1 | Mus musculus |
| 11.6 | - |
pH 7.5 | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose 1,6-diphosphate + H2O | - |
Mus musculus | D-fructose 6-phosphate + phosphate | - |
? | |
| ribulose 1,5-diphosphate + H2O | intestinal and muscle enzyme | Mus musculus | ? | - |
? | |
| sedoheptulose 1,7-bisphosphate + H2O | intestinal and muscle enzyme | Mus musculus | sedoheptulose 7-phosphate + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 38000, SDS-PAGE | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | - |
- |
Mus musculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.6 | 9 | pH 6.6: about 50% of maximal activity, pH 9.0: about 40% of maximal activity | Mus musculus |
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