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Literature summary for 3.1.3.1 extracted from

  • Sajid-Ur-Rehman, X.; Saeed, A.; Saddique, G.; Ali Channar, P.; Ali Larik, F.; Abbas, Q.; Hassan, M.; Raza, H.; Fattah, T.A.; Seo, S.Y.
    Synthesis of sulfadiazinyl acyl/aryl thiourea derivatives as calf intestinal alkaline phosphatase inhibitors, pharmacokinetic properties, lead optimization, Lineweaver-Burk plot evaluation and binding analysis (2018), Bioorg. Med. Chem., 26, 3707-3715 .
    View publication on PubMed
Search for more literature for 3.1.3.1

Inhibitors

Inhibitors Comment Organism Structure
2,4-dichloro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
-
 Bos taurus
2-chloro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
-
 Bos taurus
3,5-dinitro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
-
 Bos taurus
4-chloro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
-
 Bos taurus
4-fluoro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
-
 Bos taurus
4-methoxy-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
-
 Bos taurus
ascorbic acid
-
 Bos taurus
KH2PO4
-
 Bos taurus
N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)acetamide
-
 Bos taurus
N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)butyramide
-
 Bos taurus
N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)heptanamide
-
 Bos taurus
N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)octanamide
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.833
-
 4-nitrophenyl phosphate at pH 9.5 and 37°C Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
 Bos taurus 4-nitrophenol + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 52300, calculated from amino acid sequence Bos taurus

Synonyms

Synonyms Comment Organism
IAP
-
 Bos taurus
intestinal alkaline phosphatase
-
 Bos taurus

pI Value

Organism Comment pI Value Maximum pI Value
Bos taurus calculated from amino acid sequence
-
 5.8

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000251
-
 at pH 9.5 and 37°C Bos taurus 4-chloro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
0.000344
-
 at pH 9.5 and 37°C Bos taurus 2,4-dichloro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
0.000492
-
 at pH 9.5 and 37°C Bos taurus N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)heptanamide
0.000896
-
 at pH 9.5 and 37°C Bos taurus 3,5-dinitro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
0.001547
-
 at pH 9.5 and 37°C Bos taurus 4-fluoro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
0.001636
-
 at pH 9.5 and 37°C Bos taurus N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)butyramide
0.001704
-
 at pH 9.5 and 37°C Bos taurus N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)octanamide
0.003291
-
 at pH 9.5 and 37°C Bos taurus 4-methoxy-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
0.003458
-
 at pH 9.5 and 37°C Bos taurus 2-chloro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
0.004137
-
 at pH 9.5 and 37°C Bos taurus KH2PO4
0.004256
-
 at pH 9.5 and 37°C Bos taurus N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)acetamide