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Literature summary for 3.1.3.1 extracted from

  • Goldberg, R.F.; Austen, W.G.; Zhang, X.; Munene, G.; Mostafa, G.; Biswas, S.; McCormack, M.; Eberlin, K.R.; Nguyen, J.T.; Tatlidede, H.S.; Warren, H.S.; Narisawa, S.; Millan, J.L.; Hodin, R.A.
    Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition (2008), Proc. Natl. Acad. Sci. USA, 105, 3551-3556.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.1

Application

Application Comment Organism
medicine the brush-border enzyme, IAP, has the ability to detoxify lipopolysaccharide and prevent bacterial invasion across the gut mucosal barrier. IAP expression and function are lost with starvation and maintained by enteral feeding. It is likely that the IAP silencing that occurs during starvation is a key component of the gut mucosal barrier dysfunction seen in critically ill patients Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
human 1.6 kb IAP cDNA is subcloned into the pIRES2-EGFP vector, and the construct thus obtained (pIRES2-IAP-EGFP) is used to transfect into IEC-6, T84, and HT-29 cell lines. Stable cell lines are selected by G418 exposure Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
phenylalanine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
 Homo sapiens 4-nitrophenol + phosphate
-
 ?
additional information IAP possesses lipopolysaccharide-dephosphorylating activity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
alkaline phosphatase
-
 Homo sapiens
ALP
-
 Homo sapiens