Literature summary for 3.1.3.1 extracted from

Mota, A.; Silva, P.; Neves, D.; Lemos, C.; Calhau, C.; Torres, D.; Martel, F.; Fraga, H.; Ribeiro, L.; Alcada, M.N.; Pinho, M.J.; Negrao, M.R.; Pedrosa, R.; Guerreiro, S.; Guimaraes, J.T.; Azevedo, I.; Martins, M.J.
Characterization of rat heart alkaline phosphatase isoenzymes and modulation of activity (2008), Braz. J. Med. Biol. Res., 41, 600-609.

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Activating Compound

Activating Compound	Comment	Organism	Structure
atenolol	2 mM, 32% activation	Rattus norvegicus
corticosterone	0.5 mM, 18% activation	Rattus norvegicus
propranolol	2 mM, 18% activation	Rattus norvegicus
simvastatin	0.5 mM, 32% activation	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
aspirin	2 mM, 84% inhibition	Rattus norvegicus
corticosterone	2 mM, 13% inhibition	Rattus norvegicus
L-phenylalanine	2 mM, 24% inhibition	Rattus norvegicus
levamisole	0.5 mM, 91% inhibition	Rattus norvegicus
polyphenol-rich beverages	21% inhibition	Rattus norvegicus
progesterone	0.5 mM, 29% inhibition	Rattus norvegicus
theophylline	2 mM, 77% inhibition	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Rattus norvegicus	-
heart	expressed in heart, demonstrated by RT-PCR	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.031	-	specific activity in heart	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-nitrophenyl phosphate + H2O	-	Rattus norvegicus	4-nitrophenol + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
alkaline phosphatase	-	Rattus norvegicus
ALP	-	Rattus norvegicus
tissue-nonspecific ALP	-	Rattus norvegicus
tissue-specific intestinal ALP type II	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
10.4	-	assay at	Rattus norvegicus

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Release 2023.1 (January 2023)