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Literature summary for 3.1.26.5 extracted from

  • Magoulas, G.; Papaioannou, D.; Papadimou, E.; Drainas, D.
    Preparation of spermine conjugates with acidic retinoids with potent ribonuclease P inhibitory activity (2009), Eur. J. Med. Chem., 44, 2689-2695.
    View publication on PubMed
Search for more literature for 3.1.26.5

Inhibitors

Inhibitors Comment Organism Structure
acitretin
-
 Dictyostelium discoideum
all-trans-retinoic acid
-
 Dictyostelium discoideum
anthralin
-
 Dictyostelium discoideum
calcipotriol
-
 Dictyostelium discoideum
isotretinoin 13-cis-retinoic acid Dictyostelium discoideum
N1,N12-bis(all-trans-retinoyl)spermine
-
 Dictyostelium discoideum
N1,N12-bisacitretinylspermine
-
 Dictyostelium discoideum
N1-(all-trans-retinoyl)spermine
-
 Dictyostelium discoideum
N1-acitretinylspermine
-
 Dictyostelium discoideum
N4,N9-bis(all-trans-retinoyl)spermine
-
 Dictyostelium discoideum
retinoic acid
-
 Dictyostelium discoideum
retinol
-
 Dictyostelium discoideum
Ro 13-6298
-
 Dictyostelium discoideum
Ro 13-7410
-
 Dictyostelium discoideum
Ro 15-0778
-
 Dictyostelium discoideum
Ro 15-1570
-
 Dictyostelium discoideum

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pre-tRNA + H2O
-
 Dictyostelium discoideum tRNA + 5'-oligoribonucleotide
-
 ?

Synonyms

Synonyms Comment Organism
RNase P
-
 Dictyostelium discoideum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0005
-
 N1,N12-bis(all-trans-retinoyl)spermine at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
0.00095
-
 N1,N12-bisacitretinylspermine at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
0.0011
-
 N4,N9-bis(all-trans-retinoyl)spermine at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
0.0024
-
 N1-(all-trans-retinoyl)spermine at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
0.00245
-
 N1-acitretinylspermine at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
0.008
-
 acitretin at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
0.015
-
 all-trans-retinoic acid at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
0.02
-
 isotretinoin at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
0.045
-
 Ro 13-7410 at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
1.475
-
 retinol at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
2.8
-
 Ro 15-0778 at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
3.6
-
 Ro 15-1570 at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
4.35
-
 Ro 13-6298 at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum