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Literature summary for 3.1.26.5 extracted from
- Bacterial RNase P RNA is a drug target for aminoglycoside-arginine conjugates (2008), Bioconjug. Chem., 19, 1896-1906.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | RNase P RNA is a drug target for aminoglycoside-arginine conjugates | Bacillus subtilis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hexa-D-arginine-neomycin conjugate | - |
Bacillus subtilis |  |
| additional information | aminoglycoside-arginine conjugates and aminoglycoside poly-arginine conjugates can inhibit RNase P activity by interacting with the P protein/pre-tRNA binding site of PRNA, competing with the P protein for binding PRNA, and/or by displacing Mg2+ ions near the PRNA P15 loop leading to interference with RNase P catalysis | Bacillus subtilis | |
| neamine | - |
Bacillus subtilis | |
| neomycin B | - |
Bacillus subtilis | |
| nona-D-arginine-neamine conjugate | - |
Bacillus subtilis | |
| nona-D-arginine-neomycin conjugate | - |
Bacillus subtilis | |
| paromomycin | - |
Bacillus subtilis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | essential | Bacillus subtilis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pre-tRNA precursor + H2O | - |
Bacillus subtilis | tRNA + 5'-oligoribonucleotide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RNase P | the RNase P holoenzyme is composed of RNase P RNA and a variable number of P protein subunits | Bacillus subtilis |
| RNP | - |
Bacillus subtilis |
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