Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NeoG6 | N,N'''-[(1R,3S,4R,5R,6S)-4-[(2,6-dicarbamimidamido-2,6-dideoxy-alpha-D-glucopyranosyl)oxy]-5-[[3-O-(2,6-dicarbamimidamido-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy]-6-hydroxycyclohexane-1,3-diyl]diguanidine | Escherichia coli | |
NeoK6 | D-streptamine, O-2,6-dideoxy-2,6-bis[[(2S)-2,6-diamino-1-oxohexyl]amino]-beta-L-idopyranosyl-(1-3)-O-beta-D-ribofuranosyl-(1-5)-O-[2,6-dideoxy-2,6-bis[[(2S)-2,6-diamino-1-oxohexyl]amino]-alpha-D-glucopyranosyl-(1-4)]-2-deoxy-N1,N3-bis[(2S)-2,6-diamino-1-oxohexyl]- | Escherichia coli | |
neomycinB | - |
Escherichia coli | |
NeoR5 | D-streptamine, O-2,6-bis[[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-O-beta-D-ribofuranosyl-(1-5)-O-[2,6-bis[[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)]-N1-[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]-2-deoxy- | Escherichia coli | |
NeoR5 | D-streptamine, O-2,6-bis[[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-O-beta-D-ribofuranosyl-(1-5)-O-[2,6-bis[[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)]-N1-[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]-2-deoxy- (NeoR5), Methanothermobacter thermautotrophicus RNase P is inhibited quite significantly and progressively up to 10 microM NeoR5 | Methanothermobacter thermautotrophicus | |
NeoR5 | NeoR5 | Pyrococcus furiosus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Escherichia coli | |
Mg2+ | - |
Methanothermobacter thermautotrophicus | |
Mg2+ | - |
Pyrococcus furiosus | |
Mg2+ | - |
Methanocaldococcus jannaschii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | 5'-maturation of transfer RNA | ? | - |
? | |
additional information | Methanothermobacter thermautotrophicus | 5-maturation of transfer RNA | ? | - |
? | |
additional information | Pyrococcus furiosus | 5-maturation of transfer RNA | ? | - |
? | |
additional information | Methanocaldococcus jannaschii | 5-maturation of transfer RNA | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Methanocaldococcus jannaschii | - |
- |
- |
Methanothermobacter thermautotrophicus | - |
- |
- |
Pyrococcus furiosus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | 5'-maturation of transfer RNA | Escherichia coli | ? | - |
? | |
additional information | 5-maturation of transfer RNA | Methanothermobacter thermautotrophicus | ? | - |
? | |
additional information | 5-maturation of transfer RNA | Pyrococcus furiosus | ? | - |
? | |
additional information | 5-maturation of transfer RNA | Methanocaldococcus jannaschii | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ribonuclease P | - |
Escherichia coli |
ribonuclease P | - |
Methanothermobacter thermautotrophicus |
ribonuclease P | - |
Pyrococcus furiosus |
ribonuclease P | - |
Methanocaldococcus jannaschii |
RNase P | - |
Escherichia coli |
RNase P | - |
Methanothermobacter thermautotrophicus |
RNase P | - |
Pyrococcus furiosus |
RNase P | - |
Methanocaldococcus jannaschii |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0005 | - |
- |
Escherichia coli | NeoR5 | |
0.003 | - |
- |
Escherichia coli | NeoK6 | |
0.006 | - |
- |
Escherichia coli | NeoG6 | |
0.4 | - |
- |
Escherichia coli | neomycinB |