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Literature summary for 3.1.26.5 extracted from
- Antisense inhibition of RNase P: mechanistic aspects and application to live bacteria (2006), J. Biol. Chem., 281, 30613-30620.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DNA 14-mer | - |
Escherichia coli | |
| locked nucleic acid 14-mer | - |
Escherichia coli | |
| peptide nucleic acid 14-mer | - |
Escherichia coli | |
| peptide nucleic acid 14-mer | PNA | Pseudomonas aeruginosa | |
| peptide nucleic acid 14-mer | PNA | Thermus thermophilus | |
| RNA 14-mer | - |
Escherichia coli | |
| RNA 14-mer | - |
Pseudomonas aeruginosa | |
| RNA 14-mer | - |
Thermus thermophilus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Thermus thermophilus | essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs | ? | - |
? |  |
| additional information | Escherichia coli | essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs | ? | - |
? | |
| additional information | Pseudomonas aeruginosa | essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Pseudomonas aeruginosa | - |
- |
- |
| Thermus thermophilus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs | Thermus thermophilus | ? | - |
? | |
| additional information | essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs | Escherichia coli | ? | - |
? | |
| additional information | essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs | Pseudomonas aeruginosa | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ribonuclease P | - |
Thermus thermophilus |
| ribonuclease P | - |
Escherichia coli |
| ribonuclease P | - |
Pseudomonas aeruginosa |
| RNase P | - |
Thermus thermophilus |
| RNase P | - |
Escherichia coli |
| RNase P | - |
Pseudomonas aeruginosa |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2 | 5 | DNA 14-mer | - |
Escherichia coli | |
| 2.2 | - |
RNA 14-mer | - |
Escherichia coli | |
| 3.9 | - |
locked nucleic acid 14-mer | - |
Escherichia coli | |
| 12.5 | - |
peptide nucleic acid 14-mer | - |
Escherichia coli |
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