Literature summary for 3.1.26.5 extracted from

Toumpeki, C.; Vourekas, A.; Kalavrizioti, D.; Stamatopoulou, V.; Drainas, D.
Activation of Bacterial Ribonuclease P by Macrolides (2008), Biochemistry, 47, 4112 - 4118.

Search for more literature for 3.1.26.5

Activating Compound

Activating Compound	Comment	Organism	Structure
erythromycin	-	Escherichia coli
roxithromycin	-	Escherichia coli
spiramycin	most potent activator	Escherichia coli
tylosin	-	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pre-tRNA + H2O	Escherichia coli	Ribonuclease P (RNase P) is a ribozyme that is responsible for thematuration of 5' termini of tRNA molecules	tRNA	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pre-tRNA + H2O	Ribonuclease P (RNase P) is a ribozyme that is responsible for thematuration of 5' termini of tRNA molecules	Escherichia coli	tRNA	-	?

Synonyms

Synonyms	Comment	Organism
ribonuclease P	-	Escherichia coli
RNase P	-	Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.07	-	pre-tRNA	absence of spiramycin	Escherichia coli
0.18	-	pre-tRNA	presence of spiramycin	Escherichia coli

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Release 2023.1 (January 2023)