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Literature summary for 3.1.26.4 extracted from

  • Reverte, M.; Barvik, I.; Vasseur, J.J.; Smietana, M.
    RNA-directed off/on switch of RNase H activity using boronic ester formation (2017), Org. Biomol. Chem., 15, 8204-8210 .
    View publication on PubMed
Search for more literature for 3.1.26.4

Application

Application Comment Organism
additional information RNA-directed off/on switch of RNase H activity using boronic ester formation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information 5'-boronic acid modified oligonucleotides (ORNs) hybridized to a RNA target sequence convert RNase H into an inactivated enzyme complex. The dynamic formation of a boronate ester upon addition of a diol moiety disrupts the enzyme-inhibitor complex and reactivates RNase H. Reactivation of RNase H function can also be engineered through short RNA trimers inputs that fashion RNase H from a non-specific DNA-guided enzyme into an informational and programmable RNA-guided one. Programmable RNA recognition and cleavage, method, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens RNase H is a non-specific endonuclease which degrades selectively the RNA strand in DNA/RNA duplexes ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60930
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RNase H is a non-specific endonuclease which degrades selectively the RNA strand in DNA/RNA duplexes Homo sapiens ?
-
 ?
additional information RNase H activated cleavage of ORN3-ORN6 by incoming ribonucleotides Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
RNase H
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 Homo sapiens