Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.26.4 extracted from

  • Fluiter, K.; Mook, O.R.; Vreijling, J.; Langkjaer, N.; Hojland, T.; Wengel, J.; Baas, F.
    Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer (2009), Mol. Biosyst., 5, 838-843.
    View publication on PubMed
Search for more literature for 3.1.26.4

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
15PC3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information both modification by unlocked nucleic acids and 4'-C-hydroxymethyl-DNA gap insertions are compatible with RNase H activity when used sparingly. Multiple 4'-C-hydroxymethyl-DNA modifications are better tolerated by RNase H than multiple unlocked nucleic acid modifications in the gap Homo sapiens ?
-
 ?