Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KCl | half-maximal inhibition at 150 mM | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | divalent metal ion required. Maximal activity is obtained with 10 mM Mg2+, 5 mM Co2+ or 0.5 mM Mn2+ | Homo sapiens | |
KCl | activity increases with concentrations up to 50 mM | Homo sapiens | |
Mg2+ | divalent metal ion required. Maximal activity is obtained with 10 mM Mg2+, 5 mM Co2+ or 0.5 mM Mn2+ | Homo sapiens | |
Mn2+ | divalent metal ion required. Maximal activity is obtained with 10 mM Mg2+, 5 mM Co2+ or 0.5 mM Mn2+ | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
89000 | - |
sucrose density gradient centrifugation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
RNA-DNA hybrid + H2O | Homo sapiens | the enzyme may play a role in ribonucleotide excision from genomic DNA during replication | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
RNase H1 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
K-562 cell | K562 | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
22 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme lacks double-stranded and single-stranded RNase and DNase activities. No hydrolysis of the DNA moiety of the RNA/DNA heteroduplex | Homo sapiens | ? | - |
? | |
RNA-DNA hybrid + H2O | the enzyme can hydrolyze a DNA*RNA*DNA/DNA heteroduplex that contains a single ribonucleotide | Homo sapiens | ribonucleotide 5'-phosphomonoester | - |
? | |
RNA-DNA hybrid + H2O | poly(rUdA) | Homo sapiens | ribonucleotide 5'-phosphomonoester | - |
? | |
RNA-DNA hybrid + H2O | poly(rAdT) | Homo sapiens | ribonucleotide 5'-phosphomonoester | - |
? | |
RNA-DNA hybrid + H2O | the enzyme may play a role in ribonucleotide excision from genomic DNA during replication | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | 8.5 | in presence of 10 mM Mg2+ | Homo sapiens |