Literature summary for 3.1.26.3 extracted from

Durand, S.; Gilet, L.; Condon, C.
The essential function of B. subtilis RNase III is to silence foreign toxin genes (2012), PLoS Genet., 8, e1003181.

Search for more literature for 3.1.26.3

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	-	gene rnc	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	txpA and RatA form an extended hybrid that is a substrate for RNase III cleavage	Bacillus subtilis	?	-	?

Synonyms

Synonyms	Comment	Organism
RNase III	-	Bacillus subtilis

General Information

General Information	Comment	Organism
malfunction	in the absence of RNase III, only trace amounts of 30S rRNA precursor are observed in Bacillus subtilis. A significant increase in the steady-state levels of the type I toxin mRNA txpA occurs in strains depleted for RNase III. Expression of the txpA and yonT toxin mRNAs account for the lethality of the Skin and SPbeta prophages in RNase III mutants	Bacillus subtilis
metabolism	the enzymes that catalyze the final steps of rRNA maturation, RNase J1, Mini-III and RNase M5, function efficiently without prior RNase III action	Bacillus subtilis
physiological function	the enzyme plays a role in the mechanism of RatA mediated degradation of txpA mRNA both in vivo and in vitro and in cleaving double-stranded RNA in many biological systems, it is involved in ribosomal RNA maturation and mRNA turnover. In contrast to other bacteria, the enzyme is essential in Bacillus subtilis, it protects the organism from the expression of toxin genes borne by two prophages, through antisense RNA, although it is not responsible for the stabilities of antisense-RNAs. Degradation of type I toxin txpA is dependent on both RatA and RNase III. The organism uses RNase III or its homologues as part of viral defense or viral accommodation mechanisms	Bacillus subtilis

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Release 2023.1 (January 2023)