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Literature summary for 3.1.26.3 extracted from

  • Calin-Jageman, I.; Nicholson, A.W.
    RNA structure-dependent uncoupling of substrate recognition and cleavage by Escherichia coli ribonuclease III (2003), Nucleic Acids Res., 31, 2381-2392.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.3

Inhibitors

Inhibitors Comment Organism Structure
additional information the RNA substrate bulge-helix-bulge motif acts as a catalytic antideterminant, leading to uncoupling of substrate recognition and cleavage, not to inhibition of substrate binding Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pre-mRNA + H2O Escherichia coli enzyme regulates gene expression by controlling mRNA translation and stability mature mRNA
-
 ?
pre-rRNA + H2O Escherichia coli
-
 mature rRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RNA structure-dependent uncoupling of substrate recognition and cleavage, in vitro selection and structure determination of cleavage resistant variants of T7 R1.1 RNA classes I and II, due to altered conformation, overview Escherichia coli ?
-
 ?
pre-mRNA + H2O
-
 Escherichia coli mature mRNA
-
 ?
pre-mRNA + H2O enzyme regulates gene expression by controlling mRNA translation and stability Escherichia coli mature mRNA
-
 ?
pre-rRNA + H2O
-
 Escherichia coli mature rRNA
-
 ?
R1.1 RNA derivatives + H2O based on the R1.1 processing signal, which is encoded in the phage T7 genetic early region between genes 1.0 and 1.1, derivative R1.1[CL3B] is not cleaved and its binding to the enzyme leads to uncoupling of substrate recognition and cleavage Escherichia coli fragments of R1.1 RNA
-
 ?
RNA precursor + H2O phage lambda RNA, enzyme is involved in translation control Escherichia coli mature RNA
-
 ?

Synonyms

Synonyms Comment Organism
More the enzyme belongs to the double-stranded RNA specific RNase III family of endoribonucleases Escherichia coli
RNase III
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Escherichia coli