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Literature summary for 3.1.26.3 extracted from

  • Hostomsky, Z.; Hudson, G.O.; Rahmati, S.; Hostomska, Z.
    RNase D, a reported new activity associated with HIV-1 reverse transcriptase, displays the same cleavage specificity as Escherichia coli RNase III (1992), Nucleic Acids Res., 20, 5819-5824.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
double-stranded RNA + H2O Homo sapiens cleaves multimeric tRNA precursor at the spacer region, also involved in processing of precursor rRNA, hnRNA and early T7-mRNA. Also cleaves double-stranded DNA and single-stranded RNA 5'-phosphooligonucleotides
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
double-stranded RNA + H2O RNase D activity in HIV-1 RT is contamination Homo sapiens 5'-phosphooligonucleotides
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?
double-stranded RNA + H2O reverse transcriptase of HIV-1 possesses RNase D activity Homo sapiens 5'-phosphooligonucleotides
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?
double-stranded RNA + H2O cleaves multimeric tRNA precursor at the spacer region, also involved in processing of precursor rRNA, hnRNA and early T7-mRNA. Also cleaves double-stranded DNA and single-stranded RNA Homo sapiens 5'-phosphooligonucleotides
-
?
tRNA + H2O HIV-1 RT displays the same cleavage specificity as RNase D Homo sapiens 5'-phosphooligonucleotides
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?