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Literature summary for 3.1.26.13 extracted from

  • Herzig, E.; Hizi, A.
    The importance of glutamine 294 that affects the ribonuclease H activity of the reverse transcriptase of HIV-2 to viral replication (2015), Virology, 483, 13-20 .
    View publication on PubMed
Search for more literature for 3.1.26.13

Protein Variants

Protein Variants Comment Organism
additional information an HIV-1 mutant can tolerate an about 10fold higher RNase H activity Human Immunodeficiency Virus
additional information naturally occurring polymophisms at position 294 in HIV-2 are Q, E, L, H, and K Human Immunodeficiency Virus
Q294P site-directed mutagenesis, the Q294P mutant of HIV-2 RT has about 10fold higher RNase H activity than the wild-type. Infectious HIV-2 cannot bear the replacement of the RT's Gln294 by the HIV-1 RT Pro counterpart, as it results in substantially reduced HIV-2 replication and fast reversions to the wild-type Gln294 virus Human Immunodeficiency Virus

Inhibitors

Inhibitors Comment Organism Structure
additional information antiretroviral drugs inhibit the reverse-transcriptase (RT) of HIV. The differences between HIV-1 and HIV-2 RTs explain why some of the anti-HIV-1 drugs are not effective against HIV-2. One major difference between the two HIV RTs is the low ribonuclease H (RNase H) activity of HIV-2 RT relative to HIV-1 RT Human Immunodeficiency Virus

Organism

Organism UniProt Comment Textmining
Human Immunodeficiency Virus
-
 HIV-1
-
Human Immunodeficiency Virus
-
 HIV-2
-

Synonyms

Synonyms Comment Organism
ribonuclease H
-
 Human Immunodeficiency Virus
RNase H
-
 Human Immunodeficiency Virus

General Information

General Information Comment Organism
malfunction an HIV-1 mutant can tolerate an about 10fold higher RNase H activity Human Immunodeficiency Virus
malfunction the Q294P mutant of HIV-2 RT has about 10fold higher RNase H activity than the wild-type. Infectious HIV-2 cannot bear the replacement of the RT's Gln294 by the HIV-1 RT Pro counterpart, as it results in substantially reduced HIV-2 replication and fast reversions to the wild-type Gln294 virus. Critical role of maintaining low RT-associated RNase H activity in HIV-2 Human Immunodeficiency Virus
physiological function low ribonuclease H (RNase H) activity of HIV-2 reverse transcriptase (RT) relative to HIV-1 RT. Residue Gln294 in HIV-2 RT accounts for this RNase H reduction (the comparable residue in HIV-1 RT is Pro294), as the Q294P mutant of HIV-2 RT has about 10fold higher RNase H activity Human Immunodeficiency Virus