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Literature summary for 3.1.26.13 extracted from
- 6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H (2018), Eur. J. Med. Chem., 156, 680-691 .
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | the HIV RT-associated RNase H is avaluable drug target | Human immunodeficiency virus 1 |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,6-bis[(4-fluorophenyl)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 |  |
| 1,6-dibenzyl-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 1-(ethoxymethyl)-3-hydroxy-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 1-(ethoxymethyl)-6-[(4-fluorophenyl)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 1-benzyl-6-[(4-fluorophenyl)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 1-[[(4-fluorophenyl)methoxy]methyl]-6-[(4-fluorophenyl)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 4'-((3-(ethoxymethyl)-1-hydroxy-5-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl)-[1,1'-biphenyl]-4-carbonitrile | - |
Human immunodeficiency virus 1 | |
| 5-benzyl-6-ethyl-1-(((4-fluorobenzyl)oxy)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 5-ethyl-1-(((4-fluorobenzyl)oxy)methyl)-6-(4-fluorophenyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-( (3'- fluoro-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((2',4'-bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((2',4'-dichloro-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((2',4'-difluoro-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)methyl)-1-(ethoxymethyl)-3-hydroxy-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((3'-chloro-[1,1'-biphenyl ] - 4 -yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((3'-chloro-[1,1'-biphenyl ]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((3'-fluoro-4'-methoxy-[1,1'-biphenyl]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((3'-fluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((3'-fluoro-[1,1'-biphenyl]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((4'-chloro-3'-fluoro-[1,1'-biphenyl]-4-yl)methyl)-1-(ethoxymethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((4'-chloro-3'-fluoro-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((4'-chloro-[1,1'-biphenyl ]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((4'-fluoro-3'-methyl-[1,1'-biphenyl]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((4'-fluoro-3'-methyl-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-(3-bromobenzyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-(4-bromobenzyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-([1,1'-biphenyl]-3-ylmethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-([1,1'-biphenyl]-4-yl)-1-(ethoxymethyl)-3-hydroxy-5-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-([1,1'-biphenyl]-4-ylmethyl)-1-(ethoxymethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-([1,1'-biphenyl]-4-ylmethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methoxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-benzyl-1-(ethoxymethyl)-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-benzyl-1-[(benzyloxy)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-benzyl-1-[2-(4-fluorophenyl)ethyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-benzyl-1-[3-(4-fluorophenyl)propyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-benzyl-1-[4-(4-fluorophenyl)butyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-benzyl-1-[[(2,4-difluorophenyl)methoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-benzyl-1-[[(3-chloro-2-fluorophenyl)methoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-benzyl-1-[[(4-fluorophenyl)methoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-benzyl-1-[[3-(4-fluorophenyl)propoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-benzyl-1-[[4-(4-fluorophenyl)butoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-[(4'-chloro[1,1'-biphenyl]-3-yl)amino]-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-[([1,1'-biphenyl]-4-yl)amino]-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| additional information | 6-biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibit HIV reverse transcriptase-associated RNase H, overview. Design, synthesis, biochemical and antiviral evaluations of a 6-biphenylmethyl subtype of the 3-hydroxypyrimidine-2,4-dione (HPD) chemotype. The subtype potently inhibits RT RNase H in low nanomolar range without inhibiting RT polymerase (pol) or integrase strand transfer (INST) at the highest concentrations tested. A few analogues inhibit HIV in low micromolar range without cytotoxicity at concentrations up to 0.1 mM in cell-based assays. EC50 values and antiviral activity of the compounds, overview | Human immunodeficiency virus 1 |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human immunodeficiency virus 1 | - |
HIV-1 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | RNA/DNA duplex substrate HTS-1 (RNA 5'-gaucugagccugggagcu-3'-fluorescein annealed to DNA 3'-CTAGACTCGGACCCTCGA-5'-dabsyl) is a high sensitivity duplex assessing non-specific internal cleavage | Human immunodeficiency virus 1 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HIV reverse transcriptase-associated RNase H | - |
Human immunodeficiency virus 1 |
| HIV RT-associated RNase H | - |
Human immunodeficiency virus 1 |
| human immunodeficiency virus reverse transcriptase-associated RNase H | - |
Human immunodeficiency virus 1 |
| human immunodeficiency virus RT-associated RNase H | - |
Human immunodeficiency virus 1 |
| RT RNase H | - |
Human immunodeficiency virus 1 |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000076 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3'-fluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.0000077 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3'-fluoro-4'-methoxy-[1,1'-biphenyl]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.0000088 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-fluoro-3'-methyl-[1,1'-biphenyl]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.0000092 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',4'-dichloro-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.0000094 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-chloro-3'-fluoro-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.000011 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-fluoro-3'-methyl-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.000011 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-(4-bromobenzyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.000012 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-chloro-[1,1'-biphenyl ]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.000013 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-(3-bromobenzyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.000015 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',4'-difluoro-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.000015 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.000016 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-3-ylmethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.000016 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-4-ylmethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.000016 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3'-chloro-[1,1'-biphenyl ] - 4 -yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.000018 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3'-fluoro-[1,1'-biphenyl]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00002 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3'-chloro-[1,1'-biphenyl ]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.000025 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)pyrimidine-2,4(1H,3H)-dione | |
| 0.000028 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-( (3'- fluoro-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.000037 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione | |
| 0.000038 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.000047 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)pyrimidine-2,4(1H,3H)-dione | |
| 0.000085 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',4'-bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00022 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-[(4'-chloro[1,1'-biphenyl]-3-yl)amino]-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00025 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-[([1,1'-biphenyl]-4-yl)amino]-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00043 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-chloro-3'-fluoro-[1,1'-biphenyl]-4-yl)methyl)-1-(ethoxymethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.0009 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-benzyl-1-[4-(4-fluorophenyl)butyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.0009 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-benzyl-1-[[(3-chloro-2-fluorophenyl)methoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.0018 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-benzyl-1-[[(2,4-difluorophenyl)methoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.0018 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-benzyl-1-[[4-(4-fluorophenyl)butoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.0021 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1-(ethoxymethyl)-3-hydroxy-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)pyrimidine-2,4(1H,3H)-dione | |
| 0.0021 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-benzyl-1-[[(4-fluorophenyl)methoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.0025 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-benzyl-1-[(benzyloxy)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.0028 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-benzyl-1-[[3-(4-fluorophenyl)propoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.0038 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-benzyl-1-[3-(4-fluorophenyl)propyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.005 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-4-ylmethyl)-1-(ethoxymethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.0052 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4'-((3-(ethoxymethyl)-1-hydroxy-5-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl)-[1,1'-biphenyl]-4-carbonitrile | |
| 0.0062 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1-[[(4-fluorophenyl)methoxy]methyl]-6-[(4-fluorophenyl)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.0062 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-4-yl)-1-(ethoxymethyl)-3-hydroxy-5-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0066 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-benzyl-1-[2-(4-fluorophenyl)ethyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.0067 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)methyl)-1-(ethoxymethyl)-3-hydroxy-5-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0068 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-benzyl-1-(ethoxymethyl)-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.007 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.01 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1-benzyl-6-[(4-fluorophenyl)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.011 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methoxypyrimidine-2,4(1H,3H)-dione | |
| 0.013 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,6-bis[(4-fluorophenyl)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.015 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1,6-dibenzyl-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
| 0.015 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 5-benzyl-6-ethyl-1-(((4-fluorobenzyl)oxy)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.017 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 5-ethyl-1-(((4-fluorobenzyl)oxy)methyl)-6-(4-fluorophenyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.025 | - |
above, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1-(ethoxymethyl)-6-[(4-fluorophenyl)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione | |
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