Literature summary for 3.1.26.13 extracted from

Ilina, T.; Labarge, K.; Sarafianos, S.G.; Ishima, R.; Parniak, M.A.
Inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H activity (2012), Biology, 1, 521-541.

Search for more literature for 3.1.26.13

Inhibitors

Inhibitors	Comment	Organism	Structure
1-(3-[[(4-benzyl-5-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl]-4-methoxyphenyl)ethanone	-	Human immunodeficiency virus 1
1-hydroxy-4-[[4-(quinolin-3-yl)phenyl]amino]pyrido[2,3-d]pyrimidin-2(1H)-one	GSK5724, exceptional RNase H inhibitory potency	Human immunodeficiency virus 1
2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide	-	Human immunodeficiency virus 1
2-hydroxy-(4H)-isoquinoline-1,3-dione	inhibits RNase H in vitro with submicromolar potency	Human immunodeficiency virus 1
2-hydroxy-4-methoxycarbonylisoquinoline-1,3(2H, 4H)-dione	inhibits RNase H in vitro with nanomolar potency	Human immunodeficiency virus 1
2-oxo-2-(phenylamino)ethyl dibenzylcarbamodithioate	-	Human immunodeficiency virus 1
2-[(2-bromo-5-chloro-1-benzothiophen-3-yl)methyl]-5,6-dihydroxypyrimidine-4-carboxylic acid	-	Human immunodeficiency virus 1
3'-[(E)-[2-(3,4,5-trihydroxybenzoyl)hydrazinylidene]methyl]biphenyl-4-carboxylic acid	-	Human immunodeficiency virus 1
4-([[4-benzyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)pyridine	-	Human immunodeficiency virus 1
4-tert-butyl-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide	-	Human immunodeficiency virus 1
4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid	-	Human immunodeficiency virus 1
4-[5-(benzoylamino)thiophen-2-yl]-2,4-dioxobutanoic acid	-	Human immunodeficiency virus 1
4-[[4'-(aminomethyl)biphenyl-4-yl]methyl]-1-hydroxy-1,8-naphthyridin-2(1H)-one	-	Human immunodeficiency virus 1
6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2,4-dioxo-5-hexenoic acid ethyl ester	i.e. RDS-1643, shows relatively weak but selective inhibitory activity against RNase H	Human immunodeficiency virus 1
beta-thujaplicinol	shows submicromolar inhibitory activity against RNase H	Human immunodeficiency virus 1
dihydroxybenzoyl naphthyl hydrazone	-	Human immunodeficiency virus 1
ethyl 1,4-dihydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate	-	Human immunodeficiency virus 1
pyrimidinol carboxylic acid	-	Human immunodeficiency virus 1

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	two Mg2+ cations are essential for enzyme function	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Synonyms

Synonyms	Comment	Organism
reverse transcriptase	the multifunctional enzyme has RNA and DNA dependent polymerase activity, along with ribonuclease H activity	Human immunodeficiency virus 1
ribonuclease H	-	Human immunodeficiency virus 1
RNase H	-	Human immunodeficiency virus 1

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000003	-	pH and temperature not specified in the publication	Human immunodeficiency virus 1	1-hydroxy-4-[[4-(quinolin-3-yl)phenyl]amino]pyrido[2,3-d]pyrimidin-2(1H)-one
0.000045	-	pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-[[4'-(aminomethyl)biphenyl-4-yl]methyl]-1-hydroxy-1,8-naphthyridin-2(1H)-one
0.000061	-	pH and temperature not specified in the publication	Human immunodeficiency virus 1	2-hydroxy-4-methoxycarbonylisoquinoline-1,3(2H, 4H)-dione
0.0001	-	pH and temperature not specified in the publication	Human immunodeficiency virus 1	3'-[(E)-[2-(3,4,5-trihydroxybenzoyl)hydrazinylidene]methyl]biphenyl-4-carboxylic acid
0.00011	-	pH and temperature not specified in the publication	Human immunodeficiency virus 1	ethyl 1,4-dihydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate
0.00013	-	pH and temperature not specified in the publication	Human immunodeficiency virus 1	6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2,4-dioxo-5-hexenoic acid ethyl ester
0.00017	-	pH and temperature not specified in the publication	Human immunodeficiency virus 1	2-[(2-bromo-5-chloro-1-benzothiophen-3-yl)methyl]-5,6-dihydroxypyrimidine-4-carboxylic acid
0.0002	-	pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-([[4-benzyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)pyridine
0.0008	-	pH and temperature not specified in the publication	Human immunodeficiency virus 1	1-(3-[[(4-benzyl-5-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl]-4-methoxyphenyl)ethanone
0.0019	-	pH and temperature not specified in the publication	Human immunodeficiency virus 1	2-oxo-2-(phenylamino)ethyl dibenzylcarbamodithioate
0.002	-	pH and temperature not specified in the publication	Human immunodeficiency virus 1	2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
0.0032	-	pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-[5-(benzoylamino)thiophen-2-yl]-2,4-dioxobutanoic acid
0.0035	-	pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-tert-butyl-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide

General Information

General Information	Comment	Organism
physiological function	RNase H activity is essential for virus infectivity	Human immunodeficiency virus 1

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Release 2023.1 (January 2023)