Protein Variants | Comment | Organism |
---|---|---|
D67N | mutation involved in zidovudine resistance | Human immunodeficiency virus 1 |
E44A | mutation involved in lamivudine resistance | Human immunodeficiency virus 1 |
E44D | mutation involved in lamivudine resistance | Human immunodeficiency virus 1 |
E89K | mutation involved in foscarnet resistance | Human immunodeficiency virus 1 |
F227L | mutation involved in non-nucleoside reverse transcriptase inhibitor resistance | Human immunodeficiency virus 1 |
G190A | mutation involved in non-nucleoside reverse transcriptase inhibitor resistance | Human immunodeficiency virus 1 |
K103N | mutation involved in non-nucleoside reverse transcriptase inhibitor resistance | Human immunodeficiency virus 1 |
K219Q | mutation involved in zidovudine resistance | Human immunodeficiency virus 1 |
K65R | mutation involved in nucleos(t)ide reverse transcriptase inhibitor resistance | Human immunodeficiency virus 1 |
K65R/Q151M/A62V/V75I/F77L/F116Y | mutation involved in nucleos(t)ide reverse transcriptase inhibitor resistance | Human immunodeficiency virus 1 |
K70R | mutation involved in zidovudine resistance | Human immunodeficiency virus 1 |
L100I | mutation involved in non-nucleoside reverse transcriptase inhibitor resistance | Human immunodeficiency virus 1 |
L210W | mutation involved in zidovudine resistance | Human immunodeficiency virus 1 |
L74V | mutation involved in nucleos(t)ide reverse transcriptase inhibitor resistance | Human immunodeficiency virus 1 |
M41L | mutation involved in zidovudine resistance | Human immunodeficiency virus 1 |
Q151M | mutation involved in nucleos(t)ide reverse transcriptase inhibitor resistance | Human immunodeficiency virus 1 |
Q151M/A62V/V75I/F77L/F116Y | mutation involved in nucleos(t)ide reverse transcriptase inhibitor resistance | Human immunodeficiency virus 1 |
T215F | mutation involved in zidovudine resistance | Human immunodeficiency virus 1 |
T215Y | mutation involved in zidovudine resistance | Human immunodeficiency virus 1 |
V106A | mutation involved in non-nucleoside reverse transcriptase inhibitor resistance | Human immunodeficiency virus 1 |
W88G | mutation involved in foscarnet resistance | Human immunodeficiency virus 1 |
Y181C | mutation involved in non-nucleoside reverse transcriptase inhibitor resistance | Human immunodeficiency virus 1 |
Y188C | mutation involved in non-nucleoside reverse transcriptase inhibitor resistance | Human immunodeficiency virus 1 |
Y188L | mutation involved in non-nucleoside reverse transcriptase inhibitor resistance | Human immunodeficiency virus 1 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(2-hydroxyethoxymethyl)-6-(phenylthio)thymine | - |
Human immunodeficiency virus 1 | |
2',3'-dideoxy-3'-triaz-2-en-2-ium-3-id-1-yl-3,4-dihydrothymidine | - |
Human immunodeficiency virus 1 | |
3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-benzyl]-3H-benzothiazol-2-one | - |
Human immunodeficiency virus 1 | |
Abacavir | - |
Human immunodeficiency virus 1 | |
Delavirdine | - |
Human immunodeficiency virus 1 | |
didanosine | - |
Human immunodeficiency virus 1 | |
efavirenz | - |
Human immunodeficiency virus 1 | |
Emtricitabine | - |
Human immunodeficiency virus 1 | |
Etravirine | - |
Human immunodeficiency virus 1 | |
Foscarnet | - |
Human immunodeficiency virus 1 | |
lamivudine | - |
Human immunodeficiency virus 1 | |
loviride | - |
Human immunodeficiency virus 1 | |
additional information | mechanisms of catalysis and drug inhibition of polymerase and RNase H functions of RT by nucleos(t)ide reverse transcriptase inhibitor and non-nucleoside reverse transcriptase inhibitor drugs, and molecular mechanisms of drug resistance, detailed overview | Human immunodeficiency virus 1 | |
nevirapine | - |
Human immunodeficiency virus 1 | |
stavudine | - |
Human immunodeficiency virus 1 | |
tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one | - |
Human immunodeficiency virus 1 |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
51000 | - |
1 * 51000, p51 subunit, + 1 * 66000, p66 subunit, of HIV reverse transcriptase, SDS-PAGE | Human immunodeficiency virus 1 |
66000 | - |
1 * 51000, p51 subunit, + 1 * 66000, p66 subunit, of HIV reverse transcriptase, SDS-PAGE | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
HIV-1 | - |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 51000, p51 subunit, + 1 * 66000, p66 subunit, of HIV reverse transcriptase, SDS-PAGE | Human immunodeficiency virus 1 |
Synonyms | Comment | Organism |
---|---|---|
RNase H | - |
Human immunodeficiency virus 1 |
General Information | Comment | Organism |
---|---|---|
additional information | the RNase H activity, which degrades RNA from RNA/DNA hybrids endonucleolytically, is part of the HIV reverse transcriptase | Human immunodeficiency virus 1 |
physiological function | the reverse transcriptase generates an RNA/DNA hybrid that is a substrate for RNase H. The RNA/DNA hybrid is degraded to generate a nascent minus-strand single-stranded DNA. As DNA synthesis proceeds, RNase H degrades the RNA strand | Human immunodeficiency virus 1 |