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Literature summary for 3.1.26.13 extracted from

  • Kumar, A.
    Binding of dumbbell oligonucleotides to MoMuLV reverse transcriptase: inhibitory properties of RNase H activity (2010), E-J. Chem., 7, 701-708.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
(6,6,12,12,18,18,18-heptaoxido-5,7,11,13,17-pentaoxa-6l5,12l5,18l5-triphosphaoctadec-1-yl)phosphonate
-
Moloney murine leukemia virus
2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl 2-cyanoethyl dipropan-2-ylphosphoramidoite
-
Moloney murine leukemia virus
bis[3-(phosphonatooxy)propyl] phosphate
-
Moloney murine leukemia virus
additional information inhibitory potency and binding of dumbbell oligonucleotides to MoMuL virus RNase H, overview. The best dumbbell oligonucleotide, inhibitor contained phosphorothioate residues in both the loops Moloney murine leukemia virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Moloney murine leukemia virus retroviral reverse transcriptase also possesses a ribonuclease H activity, an enzyme which cleaves the RNA strand of RNA/DNA hetroduplex ?
-
?

Organism

Organism UniProt Comment Textmining
Moloney murine leukemia virus
-
MoMuLV
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Moloney murine leukemia virus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.6
-
commercial preparation, pH 7.8, 37°C Moloney murine leukemia virus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information retroviral reverse transcriptase also possesses a ribonuclease H activity, an enzyme which cleaves the RNA strand of RNA/DNA hetroduplex Moloney murine leukemia virus ?
-
?
additional information substrate is a 3H-UTP-labeled RNA: RNA-DNA hybrid, synthesis, overview Moloney murine leukemia virus ?
-
?

Synonyms

Synonyms Comment Organism
RNase H
-
Moloney murine leukemia virus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Moloney murine leukemia virus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Moloney murine leukemia virus

General Information

General Information Comment Organism
physiological function the retroviral RNase H degrades the RNA template following first strand synthesis, generates primers for second strand synthesis, and eliminates the t-RNA primer Moloney murine leukemia virus