Literature summary for 3.1.26.13 extracted from

Schultz, S.J.; Zhang, M.; Kelleher, C.D.; Champoux, J.J.
Analysis of plus-strand primer selection, removal, and reutilization by retroviral reverse transcriptases (2000), J. Biol. Chem., 275, 32299-32309.

Search for more literature for 3.1.26.13

Organism

Organism	UniProt	Comment	Textmining
Moloney murine leukemia virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
RNA-DNA hybrid containing the polypurine tract + H2O	extension of the polypurine tract primer by at least 2 nucleotides is sufficient for recognition and correct cleavage by RNase H at the RNA-DNA junction to remove the primer. Primer removal occurs by cleavage one nucleotide away from the RNA-DNA junction. The same polypurine tract specificity determinants responsible for generation of the polypurine tract primer also direct polypurine tract primer removal. Once the primer has been extended and removed from the nascent plus-strand DNA, reinitiation at the resulting plus-strand primer terminus does not occur	Moloney murine leukemia virus	?	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)