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Literature summary for 3.1.25.1 extracted from

  • Yarosh, D.B.
    Enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation (2002), Mutat. Res., 509, 221-226.
    View publication on PubMed

Application

Application Comment Organism
medicine application of the enzyme packaged in an engineered liposome delivery vehicle to humans suffering the disease xeroderma pigmentosum due to DNA damage by UV radiation reverses the defective repair in these cells, it traverses the stratum corneum, reaches the nuclei of living skin cells, and enhances the repair of UV-induced cyclobutane pyrimidine dimers Tequatrovirus T4
molecular biology UV-induced cell damage in xeroderma pigmentosa cells can be repaired by properly delivered T4 endonuclease V and can be used as a model for investigation of DNA repair, mutagenesis, and cell signaling without manipulation of the genome Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + H2O Tequatrovirus T4 application of the enzyme to humans suffering the disease xeroderma pigmentosum due to DNA damage by UV radiation reverses the defective repair in these cells, the enzyme influences DNA repair, mutagenesis, and cell signaling, enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation, overview ?
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?

Organism

Organism UniProt Comment Textmining
Tequatrovirus T4
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + H2O application of the enzyme to humans suffering the disease xeroderma pigmentosum due to DNA damage by UV radiation reverses the defective repair in these cells, the enzyme influences DNA repair, mutagenesis, and cell signaling, enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation, overview Tequatrovirus T4 ?
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?
DNA + H2O excision of pyrimidine dimers produced within duplex DNA by UV radiation Tequatrovirus T4 ?
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?

Synonyms

Synonyms Comment Organism
T4 endonuclease V
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Tequatrovirus T4