Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
L-DNase II | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | upon cleavage by its cognate protease, leukocyte elastase inhibitor LEI is transformed into L-DNase II, a protein with a pro-apoptotic activity. LEI/L-DNase II can interact with BCL-2 and BAX in apoptotic and non-apoptotic conditions. These proteins both inhibit the L-DNase II pro-apoptotic activity | Homo sapiens |