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Literature summary for 3.1.22.1 extracted from

  • Jaadane, I.; Nagbou, A.; Behar-Cohen, F.; Torriglia, A.
    Interaction of leukocyte elastase inhibitor/L-DNase II with BCL-2 and BAX (2014), Biochim. Biophys. Acta, 1843, 2807-2815.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
L-DNase II
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Homo sapiens

General Information

General Information Comment Organism
physiological function upon cleavage by its cognate protease, leukocyte elastase inhibitor LEI is transformed into L-DNase II, a protein with a pro-apoptotic activity. LEI/L-DNase II can interact with BCL-2 and BAX in apoptotic and non-apoptotic conditions. These proteins both inhibit the L-DNase II pro-apoptotic activity Homo sapiens