Literature summary for 3.1.22.1 extracted from

Bergsmedh, A.; Ehnfors, J.; Kawane, K.; Motoyama, N.; Nagata, S.; Holmgren, L.
DNase II and the Chk2 DNA damage pathway form a genetic barrier blocking replication of horizontally transferred DNA (2006), Mol. Cancer Res., 4, 187-195.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DNA + H2O	Mus musculus	it is proposed that DNase II together with the Chk2, p53, and p21 pathway forms a genetic barrier blocking the replication of potentially harmful DNA introduced via apoptotic bodies, thereby preventing transformation and malignant development	3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA + H2O	it is proposed that DNase II together with the Chk2, p53, and p21 pathway forms a genetic barrier blocking the replication of potentially harmful DNA introduced via apoptotic bodies, thereby preventing transformation and malignant development	Mus musculus	3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides	-	?

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Release 2023.1 (January 2023)