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Literature summary for 3.1.22.1 extracted from
- Inhibition of deoxyribonucleases by phosphorothioate groups in oligonucleotides (1988), Nucleic Acids Res., 16, 11691-11704.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| spleen | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| d[ApAp(S)ApA] + H2O | digestion of Rp- and Sp-isomers | Sus scrofa | d[Ap(S)ApA] + 3'-dAMP | after 2 h incubation, prolonged incubation leads to d[Ap(S)Ap]-Rp-isomer, dA and d[Ap(S)Ap]-Sp-isomer. Does not hydrolyse phosphorothioate internucleotidic linkage of either configuration | ? |  |
| d[ApApApA] + H2O | - |
Sus scrofa | d[ApApA] + 3'-dAMP | after 60 min of incubation, prolonged incubation leads to 3'-dAMP and dA end products in a 3 : 1 ratio | ? | |
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