Literature summary for 3.1.21.7 extracted from

Hitchcock, T.M.; Gao, H.; Cao, W.
Cleavage of deoxyoxanosine-containing oligodeoxyribonucleotides by bacterial endonuclease V (2004), Nucleic Acids Res., 32, 4071-4080.

Search for more literature for 3.1.21.7

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Co2+	supports oxanosine-containing DNA cleavage to a small extent	Salmonella sp.
Mg2+	supports oxanosine-containing DNA cleavage	Salmonella sp.
Mn2+	supports oxanosine-containing DNA cleavage	Salmonella sp.
Ni2+	supports oxanosine-containing DNA cleavage to a small extent	Salmonella sp.

Organism

Organism	UniProt	Comment	Textmining
Salmonella sp.	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA + H2O	the enzyme can cleave oxanosine-containing DNA at the second phosphodiester bond 3' to the lesion. All four oxanosine-containing base pairs (A/O), T/O, C/O and G/O are cleaved with similar efficiency. The cleavage of double-stranded oxanosine-containing DNA is about 6fold less efficient than that of double-stranded inosine-containing DNA. Single-stranded oxanosine-containing DNA is cleaved with a lower efficiency as compared with double-stranded oxanosine-containing DNA	Salmonella sp.	?	-	?

Synonyms

Synonyms	Comment	Organism
endonuclease V	-	Salmonella sp.

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Release 2023.1 (January 2023)