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Literature summary for 3.1.21.4 extracted from
- The Helicobacter pylori HpyAXII restriction-modification system limits exogenous DNA uptake by targeting GTAC sites but shows asymmetric conservation of the DNA methyltransferase and restriction endonuclease components (2008), Nucleic Acids Res., 36, 6893-6906.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli strains ER2925(DE3) and BL21(DE3) | Helicobacter pylori |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Helicobacter pylori | B6ED46 | fragment | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA + H2O | HpyAXII effectively restricts both unmethylated plasmid and chromosomal DNA during natural transformation, the enzyme targets the tetramer 5'-GTAC-3' | Helicobacter pylori | double-stranded DNA fragments with terminal 5'-phosphates | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HpyAXII | - |
Helicobacter pylori |
| type II restriction endonuclease | - |
Helicobacter pylori |
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Release 2023.1 (January 2023)
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