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Literature summary for 3.1.21.10 extracted from

  • Thakur, M.; Mohan, D.; Singh, A.K.; Agarwal, A.; Gopal, B.; Muniyappa, K.
    Novel insights into ATP-stimulated cleavage of branched DNA and RNA substrates through structure-guided studies of the Holliday junction resolvase RuvX (2021), J. Mol. Biol., 433, 167014 .
    View publication on PubMed
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Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mycobacterium tuberculosis the enzyme exhibits relaxed substrate specificity, cleaving a variety of branched DNA/RNA substrates. Notably, ATP hydrolysis plays a regulatory role, rendering the enzyme from a canonical Holliday junction resolvase to a DNA/RNA non-sequence specific endonuclease. The enzyme also has ATPase activity ?
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additional information Mycobacterium tuberculosis H37Rv the enzyme exhibits relaxed substrate specificity, cleaving a variety of branched DNA/RNA substrates. Notably, ATP hydrolysis plays a regulatory role, rendering the enzyme from a canonical Holliday junction resolvase to a DNA/RNA non-sequence specific endonuclease. The enzyme also has ATPase activity ?
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Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
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Mycobacterium tuberculosis H37Rv
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme exhibits relaxed substrate specificity, cleaving a variety of branched DNA/RNA substrates. Notably, ATP hydrolysis plays a regulatory role, rendering the enzyme from a canonical Holliday junction resolvase to a DNA/RNA non-sequence specific endonuclease. The enzyme also has ATPase activity Mycobacterium tuberculosis ?
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-
additional information the enzyme exhibits relaxed substrate specificity, cleaving a variety of branched DNA/RNA substrates. Notably, ATP hydrolysis plays a regulatory role, rendering the enzyme from a canonical Holliday junction resolvase to a DNA/RNA non-sequence specific endonuclease. The enzyme also has ATPase activity Mycobacterium tuberculosis H37Rv ?
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-

Subunits

Subunits Comment Organism
homodimer x-ray crystallography Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
HJ resolvase
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 Mycobacterium tuberculosis
Holliday junction resolvase
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 Mycobacterium tuberculosis
RuvX
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 Mycobacterium tuberculosis