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Literature summary for 3.1.21.10 extracted from

  • Long, Q.; Du, Q.; Fu, T.; Drlica, K.; Zhao, X.; Xie, J.
    Involvement of Holliday junction resolvase in fluoroquinolone-mediated killing of Mycobacterium smegmatis (2015), Antimicrob. Agents Chemother., 59, 1782-1785 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine the absence of RuvA and RuvB orthologues in humans suggests that RuvA and RuvB may serve as potential targets for clinically useful small molecule enhancers of moxifloxacin Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
wild-type ruvAB from Mycobacterium tuberculosis is cloned into pALACE, and the recombinant plasmid (pALACE-ruvAB) is introduced into strain M136 by electroporation to generate the complemented strain Mycobacterium smegmatis M136C Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WGW3 AND P9WGW1 P9WGW3: RuvA, P9WGW1: RuvB, RuvAB Holliday junction resolvase complex
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Mycobacterium tuberculosis H37Rv P9WGW3 AND P9WGW1 P9WGW3: RuvA, P9WGW1: RuvB, RuvAB Holliday junction resolvase complex
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Synonyms

Synonyms Comment Organism
Holliday junction resolvase
-
 Mycobacterium tuberculosis
RuvAB complex
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function RuvAB-dependent Holliday junction resolution appears to participate in the repair of the DNA fragmentation that initiates the protein synthesis- and ROS-dependent killing pathway Mycobacterium tuberculosis