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Literature summary for 3.1.21.10 extracted from

  • Sarbajna, S.; West, S.C.
    Holliday junction processing enzymes as guardians of genome stability (2014), Trends Biochem. Sci., 39, 409-419.
    View publication on PubMed
Search for more literature for 3.1.21.10

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + H2O Homo sapiens in contrast to GEN1, MUS81-EME1 cleaves intact Holliday junctions poorly (preferring nicked Holliday junctions, 3'-flaps, and replication fork structures as its DNA substrates). SLX1-SLX4 and MUS81-EME1 cooperatively cleave Holliday junctions by a nick and counter-nick mechanism hydrolyzed DNA
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + H2O in contrast to GEN1, MUS81-EME1 cleaves intact Holliday junctions poorly (preferring nicked Holliday junctions, 3'-flaps, and replication fork structures as its DNA substrates). SLX1-SLX4 and MUS81-EME1 cooperatively cleave Holliday junctions by a nick and counter-nick mechanism Homo sapiens hydrolyzed DNA
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Synonyms

Synonyms Comment Organism
BLM-topoisomerase IIIalpha-RMI1-RMI2 complex
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 Homo sapiens
BTR complex
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 Homo sapiens
GEN1
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 Homo sapiens
HJ-resolving enzyme
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 Homo sapiens
Holliday junction processing enzyme
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 Homo sapiens
SLX-MUS complex
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 Homo sapiens
SLX1-SLX4-MUS81-EME1 complex
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 Homo sapiens

General Information

General Information Comment Organism
malfunction the absence of SLX4 and BLM, or SLX4 and GEN1, is synthetically lethal in undamaged human cells Homo sapiens
physiological function BLM, SLX4, MUS81, and GEN1 cooperate in replication fork maintenance. BTR, SLX-MUS, and GEN1 are important for chromosome stability and faithful chromosome segregation Homo sapiens