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Literature summary for 3.1.21.10 extracted from

  • Mukherjee, S.; Wright, W.D.; Ehmsen, K.T.; Heyer, W.D.
    The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage (2014), Nucleic Acids Res., 42, 6511-6522.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + H2O Saccharomyces cerevisiae the enzyme requires inherent rotational flexibility in DNA junctions for optimal catalysis. Recognition of 3'-flap and nicked Holliday junction substrates involves induction of a sharp bend with a 100° angle between two duplex DNA arms hydrolyzed DNA
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + H2O the enzyme requires inherent rotational flexibility in DNA junctions for optimal catalysis. Recognition of 3'-flap and nicked Holliday junction substrates involves induction of a sharp bend with a 100° angle between two duplex DNA arms Saccharomyces cerevisiae hydrolyzed DNA
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?

Subunits

Subunits Comment Organism
heterodimer
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Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Eme1
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Saccharomyces cerevisiae
Holliday junction resolvase
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Saccharomyces cerevisiae
Mus81-Mms4
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Saccharomyces cerevisiae