Protein Variants | Comment | Organism |
---|---|---|
additional information | RusA restores viability to polA, dam, and uvrD mutant cells lacking RuvABC | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | RusA cleaves Holliday junctions with high specificity and efficiency, and has comparatively little activity on other forms of branched DNAs unless these can adopt a four-way branched configuration mimicking a Holliday junction | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | RusA cleaves Holliday junctions with high specificity and efficiency, and has comparatively little activity on other forms of branched DNAs unless these can adopt a four-way branched configuration mimicking a Holliday junction | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Holliday junction resolvase | - |
Escherichia coli |
ruvABC | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
malfunction | strains lacking RuvABC are inviable and accumulate Holliday junctions that interfere with growth and division of the cells | Escherichia coli |
additional information | the RegG pathway is no alternative to the RuvABC pathway for resoling Holliday junctions, since the RecG pathway is very ineffective at removing junctions. A major function of RecG is to curb potentially pathological replication initiated via PriA protein at sites remote from oriC | Escherichia coli |
physiological function | RuvABC resolves Holliday junctions, with RuvAB driving branch migration and RuvC catalyzing junction cleavage | Escherichia coli |